Skip to main content
SpringerLink
Log in

Interferon therapy for flare-up of hepatitis B virus infection after emergence of lamivudine-induced YMDD motif mutant

  • Case report
  • Published:
Journal of Gastroenterology Aims and scope Submit manuscript

Abstract:

A 61-year-old man with chronic hepatitis B was treated with interferon (IFN)-α for flare-up after the emergence of a lamivudine-induced YMDD motif mutant. The YMDD mutant emerged 13 months after the initiation of lamivudine therapy. Despite this, lamivudine therapy was continued. Acute exacerbation occurred 25 months after the emergence of the YMDD mutant. Treatment with IFN-α resulted in rapid loss of hepatitis, B virus DNA, resolution of hepatitis, and clinical recovery.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Gastroenterology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo 105-0001, Japan, , , , , , JP

    Takashi Someya, Yoshiyuki Suzuki, Yasuji Arase, Masahiro Kobayashi, Fumitaka Suzuki, Akihito Tsubota, Satoshi Saitoh, Kazuaki Chayama, Naoya Murashima, Kenji Ikeda & Hiromitsu Kumada

Authors
  1. Takashi Someya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yoshiyuki Suzuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yasuji Arase
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Masahiro Kobayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Fumitaka Suzuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Akihito Tsubota
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Satoshi Saitoh
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Kazuaki Chayama
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Naoya Murashima
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Kenji Ikeda
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Hiromitsu Kumada
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Received: December 27, 1999 / Accepted: April 28, 2000

Rights and permissions

Reprints and permissions

About this article

Cite this article

Someya, T., Suzuki, Y., Arase, Y. et al. Interferon therapy for flare-up of hepatitis B virus infection after emergence of lamivudine-induced YMDD motif mutant. J Gastroenterol 36, 133–136 (2001). https://doi.org/10.1007/s005350170143

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s005350170143

Search

Navigation