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Value of diffusion-weighted MRI in the differentiation of benign and malign breast lesions

Wertigkeit diffusionsgewichteter MRI in der Differenzierung benigner und maligner Läsionen der Brust

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Zusammenfassung

EINLEITUNG: Ziel unserer Studie war es, zu prüfen, ob eine diffusionsgewichtete MR Bildgebung (DWI) in der Differenzierung von benignen und malignen Läsionen der Brust nützlich ist. MATERIAL UND METHODEN: Es wurden 41 Frauen in die Studie eingeschlossen. Bei 45 Läsionen wurde die Diagnose bioptisch gestellt, wobei 25 (55,5 %) malign und 20 (44,5 %) gutartig waren. Der apparente Diffusions Koeffizient (ADC) dieser Läsionen wurde prospektiv mit dem histopathologischem Ergebnis verglichen. ERGEBNISSE: Als Schwellenwert zur Erkennung maligner Läsionen wurde ein ADC von 1,0×10–3 mm2/s erhoben. Die Sensitivität dieses Wertes lag bei 95 %, die Spezifität bei 100%. Der positive Voraussagewert bei 100 %, der negative bei 94 %, die Treffsicherheit -Rate bei 97 %. SCHLUSSFOLGERUNGEN: Die DWI verbessert die diagnostische Treffsicherheit der konventionelle MRI der Brust. ADC Messungen können bei der Differenzierung von malignen und benignen Läsionen der Brust nützlich sein.

Summary

INTRODUCTION: Our purpose was to determine whether diffusion-weighted MR imaging (DWI) could be used in differentiation of benign and malign breast lesions. MATERIALS AND METHODS: 41 women patients were included in the study. 45 lesions were diagnosed by biopsy; 25 (55.5%) of these lesions were malignant and 20 (44.5%) were benign. The apparent diffusion coefficient (ADC) values of these lesions were prospectively compared with their histopathological results. RESULTS: Differentiation of the malignant and benign masses revealed that the threshold value of the ADC was 1.0×10–3 mm2/s, its sensitivity was demonstrated as 95%, specificity as 100%, positive predictive as 100%, negative predictive as 94% and accuracy rate as 97%. CONCLUSIONS: DWI improves diagnostic accuracy of the conventional breast MRI. ADC measurements may be useful for differentiation of the malign and benign masses.

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Authors and Affiliations

  1. Department of Radiology, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey

    G. Sonmez, F. Cuce, H. Mutlu, M. Incedayi, E. Ozturk, O. Sildiroglu, M. Velioglu, C.C. Bashekim & E. Kizilkaya

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  1. G. Sonmez
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  2. F. Cuce
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  3. H. Mutlu
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  4. M. Incedayi
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  5. E. Ozturk
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  6. O. Sildiroglu
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  7. M. Velioglu
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  8. C.C. Bashekim
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  9. E. Kizilkaya
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Correspondence to G. Sonmez.

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Sonmez, G., Cuce, F., Mutlu, H. et al. Value of diffusion-weighted MRI in the differentiation of benign and malign breast lesions. Wien Klin Wochenschr 123, 655–661 (2011). https://doi.org/10.1007/s00508-011-0053-5

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  • DOI: https://doi.org/10.1007/s00508-011-0053-5

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