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The MAK-V protein kinase regulates endocytosis in mouse

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Abstract.

We report the cloning of a mouse cDNA encoding the MAK-V protein kinase, with a putative specificity for serine/threonine residues. The mak-v gene is transcribed in adult brain and in the mouse embryo from at least 7.5 dpc. Using the yeast two-hybrid system, we showed that MAK-V interacts with Rabaptin-5, a protein which plays an important role in endocytosis. Functional studies of the MAK-V protein suggest that it regulates endocytosis. We also constructed a human mak-v cDNA and localized the human mak-v gene at 21q22.11. Its chromosomal location suggests that mak-v could be involved in disorders of the nervous system, development or in malignancies.

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Authors and Affiliations

  1. Institute of Gene Biology, Russian Academy of Sciences. 34/5 Vavilov St., Moscow 117334, Russia, Russia

    I.V. Korobko, E.V. Korobko & S.L. Kiselev

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  1. I.V. Korobko
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  2. E.V. Korobko
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  3. S.L. Kiselev
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Korobko, I., Korobko, E. & Kiselev, S. The MAK-V protein kinase regulates endocytosis in mouse. Mol Gen Genet 264, 411–418 (2000). https://doi.org/10.1007/s004380000293

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  • DOI: https://doi.org/10.1007/s004380000293

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