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Determination of the genera of cyst-forming coccidia

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Abstract

The following heteroxenous and cyst-forming coccidian genera, Besnoitia, Cystoisospora, Frenkelia, Hammondia, Neospora, Sarcocystis and Toxoplasma have been compared biologically, and a key to determine their tissue cysts is provided.

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References

  • Ajzenberg D, Banuls AL, Tibayrenc M, Dardé M-L (2002) Microsatellite analysis of Toxoplasma gondii shows considerable polymorphism structured in two main clonal groups. Int J Parasitol 32:27–38

    Article  CAS  PubMed  Google Scholar 

  • Biocca E (1968) Class Toxoplasma tea: critical review and proposal of the new name Frenkelia gen. n. for M-organism. Parasitology 10:89–98

    Google Scholar 

  • Burtscher H (1983) Grosse Coccidien-Gewebszysten in Gehirn von Gracula religiosa (Aves: Sturnidea). Zentralbl Veterinarmed B 30:590–599

    CAS  PubMed  Google Scholar 

  • Carreno RA, Schnitzler BE, Jeffries AC, Tenter AM, Johnson AM, Barta JR (1998) Phylogenetic analysis of coccidia based on 18 rDNA sequence comparison indicates that Isospora is most closely related to Toxoplasma and Neospora. J Eukaryot Microbiol 45:184–188

    CAS  PubMed  Google Scholar 

  • Carreno RA, Martin DS, Barta JR (1999) Cryptosporidium is more closely related to the gregarines than to coccidia as shown by phylogenetic analysis of apicomplexan parasites inferred using small-subunit ribosomal RNA gene sequences. Parasitol Res 85:899–904

    CAS  PubMed  Google Scholar 

  • Clubb SL, Frenkel JK (1992) Sarcocystis falcatula of opossums: transmission by cockroaches with fatal pulmonary disease in psittacine birds. J Parasitol 78:116–124

    CAS  PubMed  Google Scholar 

  • Cohen AM, Rumpel K, Coombs GH, Wastling JM (2002) Characterisation of global protein expression by two-dimensional electrophoresis and mass spectrometry: proteomics of Toxoplasma gondii. Int J Parasitol 32:39–51

    Article  CAS  PubMed  Google Scholar 

  • Diesing L, Heydorn AO, Matuschka FR, Bauer C, Pipano E, de Waal DT, Potgieter FT (1988) Besnoitia besnoiti: studies on the definitive host and experimental infections in cattle. Parasitol Res 75:114–117

    CAS  PubMed  Google Scholar 

  • Dolezel D, Koudela B, Jirku M, et al. (1999) Phylogenetic analysis of Sarcocystis spp of mammals and reptiles supports the coevolution of Sarcocystis spp with their final hosts. Int J Parasitol 29:795–798

    CAS  PubMed  Google Scholar 

  • Dubey JP, Frenkel JK (1972) Cyst-induced toxoplasmosis in cats. J Protozool 19:155–177

    CAS  PubMed  Google Scholar 

  • Dubey JP, Lindsay DS (1996) A review of Neospora caninum and neosporosis. Vet Parasitol 67:1–59

    Article  CAS  PubMed  Google Scholar 

  • Dubey JP, Sreekumar C (2003) Redescription of Hammondia hammondi and its differentiation from Toxoplama gondii. Int J Parasitol (in press)

  • Dubey JP, Speer CA, Fayer R (1989) Sarcocystosis of animals and man, vol 1. CRC, Boca Raton, Fla., pp 1–215

  • Dubey JP, Venturioni L, Vemturini MC, Speer CA (2000) Isolation of Sarcocystis speeri Dubey and Lindsay 1999 from the South American opossum ( Didelphis albiventris) from Argentinia. J Parasitol 86:160–163

    CAS  PubMed  Google Scholar 

  • Dubey JP, Barr BC, Barta JR, Bjerkas I, Bjorkman C, Blagburn BL, Bowman DD, Buxton D, Ellis JT, Gottstein B, Hemphill A, Hill DE, Howe DK, Jenkins MC, Kobayashi Y, Koudela B, Marsh AE, Mattson JG, McAllister MM, Modry D, Omata Y, Sibley LD, Speer CA, Trees AJ, Uggla A, Upton SJ, Williams DJL, Lindsay DL (2002a) Redescription of Neospora caninum and its differentiation from related coccidia. Int J Parasitol 32:929–946

    Google Scholar 

  • Dubey JP, Lindsay DS, Rosenthal BM, Srekumar C, Hill DE, Shen SK, Kwok OCH, Rickard LG, Black SS, Rashmir-Raven A (2002b) Establishment of Besnoitia darlingi from opposums ( Didelphis virginiana) in experimental intermediate and definitive hot, propagation in cell culture, and description of ultrastructural and genetic characteristics. Int J Parasitol 32:1053–1064

    Article  CAS  PubMed  Google Scholar 

  • Dubey JP, Hill DE, Lindsey DS, Jenkins MC, Uggla A, Speer CA (2002c) Neospora caninum and Hammondi heydorni are separate species. Trends Parasitol 18:66–69

    Article  CAS  PubMed  Google Scholar 

  • Frenkel JK (1973) Toxoplasma in and around us. BioScience 23:343–352

    Google Scholar 

  • Frenkel JK (1977) Besnoitia wallacei of cats and rodents: with a reclassification of other cyst-forming isosporoid coccidia. J Parasitol 63:611–628

    CAS  PubMed  Google Scholar 

  • Frenkel JK, Dubey JP (1972) Rodents as vectors for feline coccidia, Isospora felis and Isospora rivolta. J Infect Dis 125:69–72

    CAS  PubMed  Google Scholar 

  • Frenkel J K Dubey JP(1975a) Hammondia hammondi: a new coccidium of cats producing cysts in muscle of other mammals. Science 189:222–224

    CAS  PubMed  Google Scholar 

  • Frenkel JK, Dubey JP (1975b) Hammondia hammondia gen. nov., sp. nov., from domestic cats, a new coccidian related to Toxoplasma and Sarcocystis. Z Parasitenkd 46:3–12

    CAS  PubMed  Google Scholar 

  • Frenkel JK, Dubey JP (2000) The taxonomic importance of obligate heteroxeny: distinction of Hammondia hammondi from Toxoplasma gondii. Parasitol Res 86:783–786

    Article  CAS  PubMed  Google Scholar 

  • Frenkel JK, Silva MBdeO, Saldanha JC, Silva-Vergara ML, Correia D, Barata CH, Silva EL, Ramirez LE, Prata A (2003) Presença extra-intestinal de cistos unizóicos de Isospora belli em paciente com SIDA. Relato de caso. Rev Soc Brasil Med Trop 36:409–412

    Google Scholar 

  • Garnham PCC, Duggan AJ, Sinden RE (1979) A new species of Sarcocystis in the brain of two exotic birds. Ann Parasitol 54:393–400

    CAS  Google Scholar 

  • Gondim LPF, Gao L, McAllister MM (2002) Improved production of Neospora caninum oocyst, cyclical oral transmission between dogs and cattle, and in vitro sporocyst isolation from oocysts. J Parasitol 88:1159–1163

    CAS  PubMed  Google Scholar 

  • Heydorn AO Mehlhorn H (2002) Neospora caninum is an invalid species name: an evaluation of facts and statements. Parasitol Res 8:175–184

    Article  Google Scholar 

  • Hillyer EV, Anderson MP, Greiner EC, Atkinson CT, Frenkel JK (1991) An outbreak of Sarcocystis in a collection of Psittacines. J Zool Wildl Med 22:434–445

    Google Scholar 

  • Howe DK, Sibley LD (1995) Toxoplasma gondii comprises three clonal lineages: correlations of parasite genotype with human disease J Infect Dis 172:1561–1566

    Google Scholar 

  • Jakob W, Stolte M, Odening K, Bockhard I (1988) Sarcocystis kirmsei in the brain of a hill mynah ( Gracula religiosa). J Comp Pathol 118:75–80

    Google Scholar 

  • Lindsay DS, Dubey JP (2000) Canine neosporosis. J Vet Parasitol 14:1–11

    Google Scholar 

  • Lindsay DS, Upton SJ, Toivio-Kunnucan M, McKown RD, Blagburn BL (1992) Ultrastructure of Frenkelia microti in prairie voles inoculated with sporocysts from red-tailed hawks. J Helminthol Soc Wash 59:170–176

    Google Scholar 

  • Lindsay DS, Dubey JP, Blagburn BL (1997) Biology of Isospora spp from human, nonhuman primates and domestic animals. Clin Microb Rev 10:19–34

    CAS  Google Scholar 

  • Matuschka FR (1988) Studies on the life cycle of Sarcocystis dugesii in the madeiran wall lizard Podarcis (syn. Lacerta) dugesii Parasitol Res 75:73–75

  • Matuschka FR, Hafner U (1984) Cyclic transmission of an African Besnoitia species by snakes of the genus Bitis to several rodents. Z Parasitenkd 70:451–458

    PubMed  Google Scholar 

  • Mehlhorn H, Heydorn AO (2000) Neospora caninum: is it really different from Hammondia heydorni or is it a strain of Toxoplasma gondii? An opinion. Parasitol Res 86:169–178

    CAS  PubMed  Google Scholar 

  • Mugridge NB, Morrison DA, Johnsosn AM, Luton K, Dubey JP, Votypka J, Tenter AM (1999a) Phylogenetic relationships of the genus Frenkelia: a review of its history and new knowledge gained from comparison of large subunit ribosomal ribonucleic acid gene sequences. Int J Parasitol 29:957–972

    Article  CAS  PubMed  Google Scholar 

  • Mugridge NB, Morrison DA, Heckeroth AR, Johnson AM, Tenter AM (1999b) Phylogenetic analysis based on full-length large subunit ribosomal RNA gene sequence comparison reveals the Neospora caninum is more closely related to Hammondia heydorni than to Toxoplasma gondii. Int J Parasitol 29:1545–1556

    Article  CAS  PubMed  Google Scholar 

  • Overdulve JP (1970) The identity of Toxoplasma, Nicolle and Manceaux 1909, with Isospora Schneider, 1881. K Ned Akad Wet Versl Gewone Vergad Afd Natuurkd 73:129–151

    CAS  Google Scholar 

  • Ride WDL (ed) (1999) International code of zoological nomenclature, 4th edn. London, pp 1–306

  • Romand S, Thulliez P, Dubey JP (1998) Direct agglutination test for serologic diagnosis of Neospora caninum infection. Parasitol Res 84:50–53

    Article  CAS  PubMed  Google Scholar 

  • Rommel M (1975) Neue Erkenntnisse zur Biologie der Kokzidien, Toxoplasmen, Sarkosporidien und Besnoitien. Berl Muench Tieraerztl Wochenschr 88:112–117

    CAS  Google Scholar 

  • Rommel M Krampitz, HE (1975) Beiträge zum Lebenszyklus der Frenkel ien. I. Die Idendität vom Isospora buteonis aus dem Mäusebussard mit einer Frenkel ienart ( F. clethrionomyobuteonis spec. n.) aus der Rotelmaus. Berlin Muench Tieraerztl Wochenschr 88:338–340

    CAS  Google Scholar 

  • Rommel M, Krampitz HE (1978) Weitere Untersuchungen über das Zwischenwirtsspektrum un den Entwicklungszyklus von Frenkelia microti aus der Erdmaus ( Microtus agrestis). Zentralbl Veterinaermedmed Reihe B 25:273–281

    Google Scholar 

  • Ruiz A, Frenkel JK (1978) Recognition of cyclic transmission of Sarcocystis muris by cats. J Infect Dis 133:409–418

    Google Scholar 

  • Slapeta JR, Modry D, Votypka J Jirku M, Koudela B, Lukes J (2001) Multiple origin of the dihomoxenous life cycle in sarcosporidia Internat. J Parasitol 31:413–417

    Article  CAS  Google Scholar 

  • Smith DD, Frenkel JK (1984) Besnoitia darlingi (Apicomplexa, Sarcocystidae, Toxoplasma tinae): transmission between opossums and cats. J Protozool 31:584–587

    CAS  PubMed  Google Scholar 

  • Stanek JF, Dubey JP, Oglesbee MJ, Reed SM, Lindsay DS, Capitini LA, Njoku CJ, Vittitow KL, Saville WJ (2002) Life cycle of Sarcocystis neurona in its natural intermediate host, the raccoon, Procyon lotor. J Parasitol 88:1151–8

    CAS  PubMed  Google Scholar 

  • Su C, Evans D, Cole RH, Kissinger JC, Ajioka JW, Sibley L D (2003) Recent expansion of Toxoplasma through enhanced oral transmission. Science 299:414–417

    Article  CAS  PubMed  Google Scholar 

  • Tenter A, Barta JR, Beveridge I, Duszynski DW, Mehlhorn H, Morrison DA, Thompson RCA, Conrad P (2002) The conceptual basis for a new classification of the coccidia. Int J Parasitol 32:505–616

    Google Scholar 

  • Upton SJ, McKown RD (1992) The red-tailed hawk, Buteo jamaicensis , a native definitive host of Frenkelia microti (Apicomplexa) in North America. J Wild Dis 28(1):85–90

    CAS  Google Scholar 

  • Wallace GD, Frenkel JK (1975) Besnoitia species (Protozoa, Sporozoa, Toxoplasma tidae): recognition of cyclic transmission by cats. Science188:369–371

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Acknowledgements

Original research was supported by grant AI-23730 of the National Institute of Allergy and Infectious Diseases, United States Public Health Service to J. K. F. We are indebted to Dr Donald W. Duszinski for a critical review of this paper.

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Correspondence to J. K. Frenkel.

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Frenkel, J.K., Smith, D.D. Determination of the genera of cyst-forming coccidia. Parasitol Res 91, 384–389 (2003). https://doi.org/10.1007/s00436-003-0969-4

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  • DOI: https://doi.org/10.1007/s00436-003-0969-4

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