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Neoadjuvant chemotherapy improves the survival of patients with neuroendocrine carcinoma and mixed adenoneuroendocrine carcinoma of the stomach

  • Original Article – Clinical Oncology
  • Published:
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Abstract

Purpose

The impact of neoadjuvant chemotherapy (NAC) on patients with neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinoma (MANEC) of the stomach is unclear. The aim of this retrospective study was to evaluate the effects of NAC on patients with these conditions.

Methods

This study included patients with locally advanced NEC or MANEC of the stomach who underwent gastrectomy. Histologic and prognostic effects of NAC were assessed. The overall survival (OS) rate was used to compare treatment efficacies between NAC patients and surgery-first patients.

Results

Of the 69 patients included in this study, 20 received NAC and 49 underwent surgery first after diagnosis. A total of 13 patients responded to NAC (including 3 with complete remission and 10 with partial remission) and 7 patients acquired stable disease status according to the Response Evaluation Criteria in Solid Tumors version 1.1. One patient (5%) achieved a pathological complete response after NAC. Pathological tumor regression grades 1, 2, 3, 4, and 5 were observed in 1 (5%), 5 (25%), 3 (15%), 10 (50%), and 1 (5%) patient(s) with NAC, respectively. The incidence of postoperative complications was similar in the two groups. Patients in the NAC group demonstrated better OS than did patients in the surgery-first group (P = 0.032). Multivariate analyses showed that NAC, adjuvant chemotherapy, and the clinical N stage were independent factors affecting OS.

Conclusion

In patients with locally advanced NEC and MANEC of the stomach, NAC significantly improved OS.

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Availability of data and material

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

Code availability

Not applicable.

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Funding

This work was supported by National Natural Science Foundation of China (Grant number 81772642) and Capital’s Funds for Health Improvement and Research (Grant number CFH 2018-2-4022).

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Authors and Affiliations

  1. Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Beijing, 100021, China

    Fuhai Ma, Wenzhe Kang, Yang Li, Weikun Li, Hao Liu, Shuai Ma & Yantao Tian

  2. Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China

    Bingzhi Wang & Liyan Xue

Authors
  1. Fuhai Ma
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  2. Bingzhi Wang
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  4. Wenzhe Kang
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  5. Yang Li
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  6. Weikun Li
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  7. Hao Liu
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  8. Shuai Ma
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  9. Yantao Tian
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Contributions

FM and YT conceived, designed, analyzed the data, and wrote the manuscript. WL, HL and SM analyzed the data. BW, LX, WK and YL participated in data collection. All authors reviewed the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Yantao Tian.

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Conflict of interest

The authors declare that they have no competing interests.

Ethical approval

This retrospective study was approved by the Institutional Review Board at the Cancer Hospital of the Chinese Academy of Medical Sciences. The need for informed consent was waived due to the retrospective nature of the study, and the data were anonymously analyzed.

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The datasets in the current study are available from the corresponding author on demand.

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Ma, F., Wang, B., Xue, L. et al. Neoadjuvant chemotherapy improves the survival of patients with neuroendocrine carcinoma and mixed adenoneuroendocrine carcinoma of the stomach. J Cancer Res Clin Oncol 146, 2135–2142 (2020). https://doi.org/10.1007/s00432-020-03214-w

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  • DOI: https://doi.org/10.1007/s00432-020-03214-w

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