Abstract
Purpose
Cardiac pheochromocytoma with multiple endocrine neoplasia syndrome (MENS) is rare. We present a rare case of concurrent cardiac pheochromocytoma and pituitary adenoma, a rare variant of the MEN syndromes and a review of the literature with special emphasis on diagnosis and treatment.
Methods
Different from the single MENS type I or type II, Variant MENS’ symptoms and signs are so nontypical that it is easy to make a misdiagnosis or missed diagnosis. One patient with variant MENS was treated surgically and relevant case data were collected.
Results
The perioperative course was uneventful. At 24-month follow-up, catecholamine levels returned to normal and no symptoms of pheochromocytoma was found.
Conclusions
Cardiac pheochromocytoma with Multiple Endocrine Neoplasia can be treated by operation with good prognosis. Surgical removal to provide relief or effective control of symptoms is the treatment of choice.
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References
Breckenridge SM, Hamrahian AH, Faiman C, Suh J, Prayson R, Mayberg M (2003) Coexistence of a pituitary macroadenoma and pheochromocytoma–a case report and review of the literature. Pituitary 6:221–225
Falchetti A, Marini F, Luzi E, Tonelli F, Brandi ML (2008) Multiple endocrine neoplasms. Best Pract Res Clin Rheumatol 22(1):149–163
Grumbach MM, Biller BM, Braunstein GD (2003) Management of the clinically inapparent adrenal mass (“incidentaloma”). Ann Intern Med 138:424–429
Lin JC, Palafox BA, Jackson HA, Cohen AJ, Gazzaniga AB (1999) Cardiac pheochromocytoma: resections after diagnosis by 111-indium octreotide scan. Ann Thorac Surg 67:555–558
Schimke R (1990) Multiple endocrine neoplasia: how many syndromes? Am J Med Genet 37:375–383
van der Harst E, de Herder WW, Bruining HA, Bonjer HJ, de Krijger RR, Lamberts SW et al (2001) [(123)I]metaiodobenzylguanidine and [(111)In]octreotide uptake in begnign and malignant pheochromocytomas. J Clin Endocrinol Metab 86:685–693
Yaylali GF, Akin F, Bastemir M, Yaylali YT, Ozden A (2008) Phaeochromocytoma combined with subclinical Cushing’s syndrome and pituitary microadenoma. Clin Invest Med 31:E176–E181
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Zhang, C., Ma, G., Liu, X. et al. Primary cardiac pheochromocytoma with Multiple Endocrine Neoplasia. J Cancer Res Clin Oncol 137, 1289–1291 (2011). https://doi.org/10.1007/s00432-011-0985-1
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DOI: https://doi.org/10.1007/s00432-011-0985-1