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Histological changes secondary to wire coil placement in breast tissue and lymph nodes

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Abstract

We describe the histological and immunohistochemical features of the changes produced by spiral coil localization wires in the breast parenchyma and lymph nodes of a total of 100 patients undergoing surgery for different breast lesions. Coil wires produced cystic lesions containing a hyaline, mucous-like, PAS-negative fluid. Cavities were lined by cells of variable morphology ranging from synovial-like cells (with a conspicuous epithelial appearance) to mononuclear or multinucleate histiocytic cells that expressed CD68, but were negative for keratins. CD3-positive/CD8-positive T lymphocytes predominated in the inflammatory reaction. Pathologists should be aware of these changes in order to differentiate coil-related lesions from other granulomatous or epithelial lesions, including mucocele-like and ductal carcinoma in situ lesions.

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Funding

This project was supported by grants from Instituto Carlos III (ISCIII) (PI16/00887, PT13/0010/0056, PIE15/00050) and CIBERONC (CB16/12/00316), co-financed by the European Development Regional Fund. ‘A way to achieve Europe’ (FEDER), by the AECC (AIO-AECC 2016), and by Fundació La Marató de TV3 (2/C2013). JMRR is a PhD investigator funded by ISCIII (CB16/12/00316).

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Authors and Affiliations

  1. Pathology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain

    Ignacio Pinilla-Pagnon, Belén Pérez-Mies, María Eugenia Reguero, Marco-Tulio Martinez & José Palacios

  2. Breast Pathology Unit, Hospital Universitario Ramón y Cajal, Madrid, Spain

    Belén Pérez-Mies, María Eugenia Reguero, Miguel Chiva, Silvia Pérez-Rodrigo, Maria Eugenia Rioja Martin, Maria Vicenta Collado, Maria Concepción Sanchez & José Palacios

  3. Radiology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain

    Miguel Chiva & Silvia Pérez-Rodrigo

  4. Nuclear Medicine Department, Hospital Universitario Ramón y Cajal, Madrid, Spain

    Odile Ajuria Illarramendi & Maria Eugenia Rioja Martin

  5. General Surgery Department, Hospital Universitario Ramón y Cajal, Madrid, Spain

    Maria Vicenta Collado

  6. Obstetrics and Gynecology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain

    Maria Concepción Sanchez

  7. Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain

    Juan Manuel Rosa-Rosa & José Palacios

  8. IRyCIS, Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramón y Cajal, Madrid, Spain

    José Palacios

  9. Universidad de Alcalá de Henares, Madrid, Spain

    José Palacios

Authors
  1. Ignacio Pinilla-Pagnon
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  2. Belén Pérez-Mies
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  3. María Eugenia Reguero
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  4. Marco-Tulio Martinez
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  5. Miguel Chiva
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  6. Silvia Pérez-Rodrigo
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  7. Odile Ajuria Illarramendi
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  8. Maria Eugenia Rioja Martin
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  9. Maria Vicenta Collado
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  10. Maria Concepción Sanchez
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  11. Juan Manuel Rosa-Rosa
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  12. José Palacios
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Corresponding author

Correspondence to José Palacios.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

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The authors declare that they have no conflict of interest.

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Pinilla-Pagnon, I., Pérez-Mies, B., Reguero, M.E. et al. Histological changes secondary to wire coil placement in breast tissue and lymph nodes. Virchows Arch 473, 285–291 (2018). https://doi.org/10.1007/s00428-018-2399-9

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  • DOI: https://doi.org/10.1007/s00428-018-2399-9

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