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Symptomatic paroxysmal kinesigenic choreoathetosis as primary manifestation of multiple sclerosis

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Fig. 1

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Acknowledgments

Dr. Zittel is supported by the Wegener Stiftung and has received research support by Merz Pharmaceuticals. Dr. Gerloff was supported by advisory boards of Boehringer Ingelheim and Silk Road Medical, and by grants from the DFG (Ge 844/2-1, Ge 844/4-1), the Bundesministerium für Bildung und Forschung (BMBF competence net stroke, BMBF Multicare), and UKE intramural grants. Dr. Münchau is supported by the Deutsche Forschungsgemeinschaft (MU1692/2-2). He received research support and honoraria for lectures by Pharm Allergan, Ipsen, Merz Pharmaceuticals. He is supported by the Dystonia Medical Research Foundation (USA), the Tourette Syndrome Association (Germany) and N.E.MO., charity supporting the research of paediatric movement disorders.

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Authors and Affiliations

  1. Department of Neurology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany

    Simone Zittel, Christian Gerloff, Alexander Münchau & Frank Leypoldt

  2. Department of Neuroradiology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany

    Maxim Bester

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  1. Simone Zittel
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  2. Maxim Bester
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  3. Christian Gerloff
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  4. Alexander Münchau
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  5. Frank Leypoldt
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Corresponding author

Correspondence to Frank Leypoldt.

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Segment 1 (Patient 1) When running on the spot, the patient experiences bradykinesia of right hand and arm after 30 s with associated dystonia and slight chorea. She describes a tingling sensation of right arm and leg. A similar but more intense right sided dystonia and chorea can be elicited by 90 s of hyperventilation and subsides 20 s later. During the attacks symptoms showed a crescendo-decrescendo dynamic. Segment 2 (Patient 2) While running on the spot for 30 s, generalized predominantly right-sided chorea, appendicular and axial dystonia develop accompanied by a “cramp-like” sensation and “pressed” dystonic dysarthria. Symptoms resolved after 60 s (MPG 35100 kb)

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Zittel, S., Bester, M., Gerloff, C. et al. Symptomatic paroxysmal kinesigenic choreoathetosis as primary manifestation of multiple sclerosis. J Neurol 259, 557–558 (2012). https://doi.org/10.1007/s00415-011-6188-5

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  • DOI: https://doi.org/10.1007/s00415-011-6188-5

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