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Immune responses to different patterns of exposure to ovalbumin in a mouse model of allergic rhinitis

  • Rhinology
  • Published:
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Abstract

Allergic rhinitis (AR) has been a significant healthcare burden on individuals and society. However, the detailed effect of different patterns of allergen exposure on the development of AR remains controversial. A mouse model of AR was established to address the complex relationships between allergen exposure and the development of AR. Allergic symptom, OVA-specific IgE in serum and nasal lavage fluid, allergic inflammation in nasal tissues were evaluated after intranasal sensitization and challenge of ovalbumin (OVA) in mice treated with two different doses of allergen for different sensitized durations. Exposure to different doses and sensitized durations of OVA were capable of inducing allergic nasal response. Repetitive OVA exposure in the sensitization phase induced the recruitment of eosinophils and goblet cell hyperplasia. The level of OVA-specific IgE in serum depended on OVA exposure and was mediated in a duration-related manner. In addition, mice treated with low-dose OVA for prolonged duration manifested the major features of human local allergic rhinitis. There were dose- and duration-related effects of allergen exposure on the development of AR. LAR was associated with repetitive exposure to low-dose allergen. Thus, allergen avoidance should be an important aim of AR management.

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Acknowledgments

This study was supported by grants from the Science and Technology Program of Guangdong, China (2013B021800112) and the National Natural Science Foundation of Guangdong, China (2014A030313106).

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Authors and Affiliations

  1. Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, Guangdong, China

    Mei-Jun Liang, Qing-Ling Fu, Feng-Hong Chen, Dong Chen, De-Hua Chen, Zhi-Bin Lin & Rui Xu

  2. Department of Otorhinolaryngology, Hainan General Hospital, Haikou, China

    Hong-Yan Jiang

Authors
  1. Mei-Jun Liang
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  2. Qing-Ling Fu
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  3. Hong-Yan Jiang
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  5. Dong Chen
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  6. De-Hua Chen
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  7. Zhi-Bin Lin
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  8. Rui Xu
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Corresponding author

Correspondence to Rui Xu.

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Ethical standards

All procedures performed in this study were in accordance with the ethical standards of the Animal Ethical and Welfare Committee.

Fundings

This study was supported by grants from the Science and Technology Program of Guangdong, China (2013B021800112) and the National Natural Science Foundation of Guangdong, China (2014A030313106).

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The authors declare that they have no conflict of interest.

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Liang, MJ., Fu, QL., Jiang, HY. et al. Immune responses to different patterns of exposure to ovalbumin in a mouse model of allergic rhinitis. Eur Arch Otorhinolaryngol 273, 3783–3788 (2016). https://doi.org/10.1007/s00405-016-4128-9

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  • DOI: https://doi.org/10.1007/s00405-016-4128-9

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