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Prophylactic effectiveness of budesonide inhalation in reducing postoperative throat complaints

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Postoperative sore throat (POST) is one of the main postoperative complaints. This study was to evaluate the efficacy of budesonide inhalation suspension (BIS) in reducing the incidence and severity of POST. One hundred and twenty patients scheduled for thyroid surgery with general anesthesia were enrolled and randomized into three groups. Group A received 200 mcg BIS 10 min prior to the tracheal intubation and received the same treatment 6 and 24 h after extubation. Group B received 200 mcg BIS 6 and 24 h after extubation. Control group received the same scheduled treatment as Group A, but the BIS was replaced with 2 ml normal saline. The patients were evaluated for sore throat and hoarseness 1, 24 and 48 h after extubation. The status of laryngopharynx was also recorded. There was no statistically significant difference in the incidence of sore throat among three groups. However, hoarseness occurred significantly less frequently in Group A (P < 0.05). One hour after extubation, Group A exhibited significantly less severe sore throat and hoarseness compared to the other two groups (P < 0.05), which disappeared 24 h later. The mucositis scores of laryngopharynx at 1, 24 and 48 h post-extubation were significantly lower in Group A (P < 0.05). BIS can reduce the incidence and severity of the POST prophylactically.

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References

  1. Jung TH, Rho J-H, Hwang JH et al (2011) The effect of the humidifier on sore throat and cough after thyroidectomy. Korean J Anesthesiol 61(6):470–474

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. Tazeh-kand NF, Eslami B, Mohammdian K (2010) Inhaled fluticasone propionate reduces postoperative sore throat, cough, and hoarseness. Anesth Analg 111:895–898

    CAS  PubMed  Google Scholar 

  3. Huang YS, Hung NK, Lee MS et al (2010) The effectiveness of benzydamine hydrochloride spraying on the endotracheal tube cuff or oral mucosa for postoperative sore throat. Anesth Analg 111(4):887–891

    CAS  PubMed  Google Scholar 

  4. Sumathi PA, Shenoy T, Ambareesha M, Krishna M (2008) Controlled comparison between betamethasone gel and lidocaine jelly applied over tracheal tube to reduce postoperative sore throat, cough, and hoarseness of voice. Br J Anaesth 100:215–218

    Article  CAS  PubMed  Google Scholar 

  5. Ebneshahidi A, Mohseni M (2010) Strepsils® tablets reduce sore throat and hoarseness after tracheal intubation. Anesth Analg 111(4):892–894

    CAS  PubMed  Google Scholar 

  6. Liu HP, Xue FS, Liu JH, Guo XL, Liao X (2011) Application of triamcinolone acetonide paste to the endotracheal tube to reduce postoperative sore throat. Can J Anaesth 58(9):873–874

    Article  PubMed  Google Scholar 

  7. Agarwal A, Nath SS, Goswami D et al (2006) An evaluation of the efficacy of aspirin and benzydamine hydrochloride gargle for attenuating postoperative sore throat: a prospective, randomized, single-blind study. Anesth Analg 103:1001–1003

    Article  CAS  PubMed  Google Scholar 

  8. Agarwal A, Gupta D, Yadav G, Goyal P, Singh PK, Singh U (2009) An evaluation of the efficacy of licorice gargle for attenuating postoperative sore throat: a prospective, randomized, single-blind study. Anesth Analg 109(1):77–81

    Article  CAS  PubMed  Google Scholar 

  9. Park SY, Kim SH, Lee AR, Cho SH, Chae WS et al (2010) Prophylactic effect of dexamethasone in reducing postoperative sore throat. Korean J Anesthesiol 58(1):15–19

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Biro P, Seifert B, Pasch T (2005) Complaints of sore throat after tracheal intubation: a prospective evaluation. Eur J Anaesthesiol 22(4):307–311

    Article  CAS  PubMed  Google Scholar 

  11. McHardy FE, Chung F (1999) Postoperative sore throat: cause, prevention and treatment. Anaesthesia 54:444–453

    Article  CAS  PubMed  Google Scholar 

  12. Miller KA, Harkin CP, Bailey PL (1995) Postoperative tracheal extubation. Anesth Analg 80:149–172

    CAS  PubMed  Google Scholar 

  13. Kadri IA, Khanzada TW, Samad A (2009) Post-thyroidectomy sore throat: a common problem. Par J Med Sci 25:408–412

    Google Scholar 

  14. Combes X, Schauvliege F, Peyrouset O, Motamed C, Kirov K, Dhonneur G, Duvaldestin P (2001) Intracuff pressure and tracheal morbidity: influence of filling with saline during nitrous oxide anesthesia. Anesthesiology 95(5):1120–1124

    Article  CAS  PubMed  Google Scholar 

  15. Christensen AM, Willemoes-Larsen H, Lundby L, Jzkobsen KB (1994) Postoperative throat complaints after tracheal intubation. Br J Anaesth 73:786–787

    Article  CAS  PubMed  Google Scholar 

  16. Park SH, Han SH, Do SH, Kim JW, Rhee KY et al (2008) Prophylactic dexamethasone decreases the incidence of sore throat and hoarseness after tracheal extubation with a double-lumen endotube. Analg 107:1814–1818

    Article  CAS  Google Scholar 

  17. Maruyama K, Sakal H, Miyazawa H, Toda N, Iinuma Y et al (2004) Sore throat and hoarseness after total intravenous anaesthesia. Br J Anaesth 92:541–543

    Article  CAS  PubMed  Google Scholar 

  18. Chen KT, Tzeng JI, Lu CL, Liu KS, Chen YW, Hsu CS, Wang JJ (2004) Risk factors associated with postoperative sore throat after tracheal intubation: an evaluation in the postanesthetic recovery room. Acta Anaesthesiol Taiwan 42(1):3–8

    PubMed  Google Scholar 

  19. Tu NH, Duvaldestin P (2005) Post-operative sore throat and hoarseness as a result of endotracheal tube positioning in thyroidectomy. VISTA 34:81–86

    Google Scholar 

  20. Keijzer C, Buitelaar DR, Efthymiou KM, Srámek M, ten Cate J (2009) A comparison of postoperative throat and neck complaints after the use of the i-gel and the La Premiere disposable laryngeal mask: a double-blinded, randomized, controlled trial. Anesth Analg 109(4):1092–1095

    Article  PubMed  Google Scholar 

  21. Honarmand A, Safavi M (2008) Beclomethasone inhaler versus intravenous lidocaine in the prevention of postoperative airway and throat complaints: a randomized, controlled trial. Ann Saudi Med 28(1):11–16

    Article  PubMed  Google Scholar 

  22. Guilbert TW, Morgan WJ, Zeiger RS, Mauger DT, Boehmer SJ, Szefler SJ et al (2006) Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med 354:1985–1997

    Article  CAS  PubMed  Google Scholar 

  23. Scott LJ (2012) Budesonide/formoterol Turbuhaler®: a review of its use in chronic obstructive pulmonary disease. Drugs 72(3):395–414

    Article  CAS  PubMed  Google Scholar 

  24. Wei JL, Kasperbauer JL, Weaver AL, Boggust AJ (2002) Efficacy of single-dose dexamethasone as adjuvant therapy for acute pharyngitis. Laryngoscope 112:87–93

    Article  CAS  PubMed  Google Scholar 

  25. Demoly P (2008) Safety of intranasal corticosteroids in acute rhinosinusitis. Am J Otolaryngol 29:403–413

    Article  CAS  PubMed  Google Scholar 

  26. Leflein JG, Baker JW, Eigen H, Lyzell E, McDermott L (2005) Safety features of budesonide inhalation suspension in the long-term treatment of asthma in young children. Adv Ther 22(3):198–207

    Article  CAS  PubMed  Google Scholar 

  27. De Benedictis FM, Del Giudice MM, Vetrella M, Tressanti F, Tronci A, Flic 12 Study Group et al (2005) Nebulized fluticasone propionate vs. budesonide as adjunctive treatment in children with asthma exacerbation. J Asthma 42(5):331–336

    Article  PubMed  Google Scholar 

  28. Frhim A, Faruqi S, Wright CE, Kastelik JA, Morice AH (2012) Comparison of the effect of high-dose inhaled budesonide and fluticasone on adrenal function in patients with severe chronic obstructive pulmonary disease. Ann Thorac Med 7(3):140–144

    Article  Google Scholar 

  29. Celik O, Niyazoglu M, Soylu H, Kadioglu P (2012) Iatrogenic Cushing’s syndrome with inhaled steroid plus antidepressant drugs. Multidiscip Respir Med 7(1):26

    Article  PubMed Central  PubMed  Google Scholar 

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Conflict of interest

Authors indicate they have no financial relationship with the organization that sponsored the research. And the authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Oto-Rhino-Laryngology Surgery, Ren Ji Hospistal, School of Medicine, Shanghai Jiao Tong University, Building 10, No. 1630, DongFang Road, 200127, Shanghai, China

    Yan-Qing Chen & Ji-Ping Li

  2. Oto-Rhino-Laryngology Institute of Shanghai Jiao Tong University, 200127, Shanghai, China

    Yan-Qing Chen & Ji-Ping Li

  3. Department of Anaesthesia, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 200127, Shanghai, China

    Jie Xiao

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  1. Yan-Qing Chen
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Correspondence to Ji-Ping Li.

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Chen, YQ., Li, JP. & Xiao, J. Prophylactic effectiveness of budesonide inhalation in reducing postoperative throat complaints. Eur Arch Otorhinolaryngol 271, 1667–1672 (2014). https://doi.org/10.1007/s00405-014-2896-7

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  • DOI: https://doi.org/10.1007/s00405-014-2896-7

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