Abstract
Chronic rhinosinusitis is a symptomatic inflammation of the mucosa of the nose and paranasal sinuses lasting for at least 12 weeks. Atypical bacteria Chlamydophila pneumoniae and Mycoplasma pneumoniae are important causes of human respiratory tract infection. Also, they were identified in bronchial respiratory epithelium of patients with chronic obstructive pulmonary disease or asthma. Having in mind the unified airway concept, it is also possible that these bacteria can cause persistent infection of sinus mucosa in patients with chronic rhinosinusitis. Sixty consecutive patients with chronic rhinosinusitis who underwent the functional endoscopic sinus surgery due to medical therapy failure were included in the study. During the operation, sinuses were irrigated with sterile 0.9 % NaCl solution and this lavage was immediately aspirated. Aspirates were used for the detection of C. pneumoniae and M. pneumoniae DNA using real-time PCR. C. pneumoniae and M. pneumoniae DNA were not detected in samples analysed. Atypical bacteria C. pneumoniae and M. pneumoniae did not cause persistent infection of sinus mucosa in patients with chronic rhinosinusitis.
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References
Schleimer RP, Kato A, Peters A et al (2009) Epithelium, inflammation and immunity in the upper airways of humans. Proc Am Thorac Soc 6:288–294
Blasi F (2004) Atypical pathogens and respiratory tract infections. Eur Respir J 24:171–181
Meltzer EO, Szwarcberg J, Pill MW (2004) Allergic rhinitis, asthma, and rhinosinusitis: diseases of the integrated airway. J Manag Care Pharm 10:310–317
Pandak N, Pajić-Penavić I, Sekelj A, Tomić-Paradžik M, Cabraja I, Miklaušić B (2011) Bacterial colonization or infection in chronic sinusitis. Wien Klin Wochenschr 123:710–713
Haug RH (2012) Microorganisms of the nose and paranasal sinuses. Oral Maxillofac Surg Clin North Am 24:191–196
Lin DC, Chandra RK, Tan BK et al (2011) Association between severity of asthma and degree of chronic rhinosinusitis. Am J Rhinol Allergy 25:205–208
Kelemence A, Abadoglu O, Gumus C, Berk S, Epozturk K, Akkurt I (2011) The frequency of chronic rhinosinusitis/nasal polyp in COPD and its effect on the severity of COPD. COPD 8:8–12
Teig N, Anders A, Schmidt C, Rieger C, Gatermann S (2005) Chlamydophila pneumoniae and Mycoplasma pneumoniae in respiratory specimens of children with chronic lung diseases. Thorax 60:962–966
Specjalski K, Jassem E (2011) Chlamydophila pneumoniae, Mycoplasma pneumoniae infections, and asthma control. Allergy Asthma Proc 32:9–17
Kern JM, Maass V, Maass M (2009) Molecular pathogenesis of chronic Chlamydia pneumoniae infection: a brief overview. Clin Microbiol Infect 15:36–41
Cultrara A, Goldstein NA, Ovchinsky A, Reznik T, Roblin PM, Hammerschlag MR (2003) The role of Chlamydia pneumoniae infection in children with chronic sinusitis. Arch Otolaryngol Head Neck Surg 129:1094–1097
Fahrenholz J, Stratton C, Wolf B et al (2008) Chlamydophila pneumoniae and chronic sinusitis. J Allergy Clin Immunol 121:S217
Lee RE, Kaza S, Plano GV, Casiano RR (2005) The role of atypical bacteria in chronic rhinosinusitis. Otolaryngol Head Neck Surg 133:407–410
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Pandak, N., Pajić-Penavić, I., Židovec-Lepej, S. et al. Chlamydophila pneumoniae and Mycoplasma pneumoniae were not identified in sinus mucosa of patients with chronic rhinosinusitis. Eur Arch Otorhinolaryngol 271, 1553–1555 (2014). https://doi.org/10.1007/s00405-013-2745-0
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DOI: https://doi.org/10.1007/s00405-013-2745-0