Skip to main content

Advertisement

Log in

Intravenous immunoglobulin replacement therapy for common variable immunodeficiency during pregnancy

  • Case Report
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Patients with common variable immunodeficiency (CVID), characterized by impaired antibody production, have a high susceptibility to bacterial infections and need supplements of immunoglobulin G (IgG). We report two pregnancies in a woman with CVID. Differences in the outcome of the two pregnancies suggest the need for adjustment of replacement therapy during pregnancy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Amarin ZO, Grant KA (1992) Hypogammaglobulinaemia during pregnancy in identical twin sisters. Int J Gynaecol Obstet 20:471–473

    Article  Google Scholar 

  • Madsen DL, Catanzarite VA, Varela-Gittings F (1986) Common variable hypogammaglobulinemia in pregnancy: treatment with high-dose immunoglobulin infusions. Am J Hematol 21:327–329

    Article  PubMed  CAS  Google Scholar 

  • Ochs HD, Fischer SH, Wedgwood RJ et al. (1984) Comparison of high-dose and low-dose intravenous immunoglobulin therapy in patients with primary immunodeficiency diseases. Am J Med 76:78–82

    Article  PubMed  CAS  Google Scholar 

  • Roifman CM, Levison H, Gelfand EW (1987) High-dose versus low-dose intravenous immunoglobulin in hypogammaglobulinaemia and chronic lung disease. Lancet 1:1075–1077

    Article  PubMed  CAS  Google Scholar 

  • Sacher RA, King JC (1989) Intravenous gamma-globulin in pregnancy: a review. Obstet Gyne-col Surv 44:25–34

    Article  CAS  Google Scholar 

  • Schaffer FM, Newton JA (1994) Intravenous gamma globulin administration to common variable immunodeficient women during pregnancy: case report and review of the literature. J Perinatol 14:114–117

    PubMed  CAS  Google Scholar 

  • Smith CI, Hammarstrom L (1985) Intravenous immunoglobulin in pregnancy. Obstet Gynecol 66:39S-40S

    PubMed  CAS  Google Scholar 

  • Sneller MC, Strober W, Eisenstein E, Jaffe JS, Cunningham-Rundles C (1993) NIH conference. New insights into common variable immunodeficiency. Ann Intern Med 118:720–730

    PubMed  CAS  Google Scholar 

  • Sorensen RU, Tomford JW, Gyves MT, Judge NE, Polmar SH (1984) Use of intravenous immune globulin in pregnant women with common variable hypogammaglobulinemia. Am J Med 76:73–77

    Article  PubMed  CAS  Google Scholar 

  • Willimas PE, Leen CL, Heppleston AD, Yap PL (1990) IgG replacement therapy for primary hypogammaglobulinaemia during pregnancy: report of 9 pregnancies in 4 patients. Blut 60:198–201

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Osada, H., Morikawa, Y., Nishiwaki, T. et al. Intravenous immunoglobulin replacement therapy for common variable immunodeficiency during pregnancy. Arch Gynecol Obstet 258, 155–159 (1996). https://doi.org/10.1007/s004040050118

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s004040050118

Key words

Navigation