Abstract
Purpose
To investigate the association between kisspeptin 10 (Kp-10) levels and early pregnancy bleeding and perinatal outcome.
Methods
A total of 20 pregnant women with the complaint of vaginal bleeding during 7–18 gestational weeks and 20 healthy gestational week matched pregnant women were included in the study. Maternal plasma Kp-10 levels were measured with the enzyme immunoassay method. Adverse pregnancy outcomes like intrauterine growth restriction, preterm delivery, preeclampsia and low birth weight were evaluated in both groups.
Results
Maternal plasma Kp-10 levels (p = 0.01) and birth weight (p = 0.06) were found to be lower in women with bleeding. Intrauterine growth restriction, preterm delivery and intrauterine exitus were noted more commonly in women with bleeding (10 vs. 0%, 25 vs. 15% and 20 vs. 0%, p = 0.08). Preeclampsia were developed in 5% of both groups. Kp-10 levels showed positive correlation with gestational week (p = 0.02) and ALT levels (p = 0.02).
Conlusion
Kp-10 levels were found lower in women with early pregnancy bleeding.
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Acknowledgments
We thank to doctors and nurses of Firat University School of Medicine, Department of Obstetric and Gynecology for the help provided during our study. This study has been supported by Firat University Scientific Research Foundation.
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All of the doctors have no conflict of interest.
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Kavvasoglu, S., Ozkan, Z.S., Kumbak, B. et al. Association of kisspeptin-10 levels with abortus imminens: a preliminary study. Arch Gynecol Obstet 285, 649–653 (2012). https://doi.org/10.1007/s00404-011-2061-0
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DOI: https://doi.org/10.1007/s00404-011-2061-0