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Hormone replacement therapy: relation to homocysteine and prooxidant-antioxidant status in healthy postmenopausal women

  • General Gynecology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objectives

Studies have consistently shown a lower cardiovascular risk in women who received postmenopausal hormone replacement therapy (HRT).

Design and Methods

In this study, the effects of HRT were investigated on plasma total homocysteine (tHcy) and the oxidant-antioxidant status in postmenopausal women. 35 of postmenopausal receiving (2 mg estrodiol valerate + 1 mg cyproterone acetate) HRT group, the remaining 25 received orally placebo (NHRT group).

Results

There was no significant change in plasma tHcy levels between HRT and NHRT groups. Malondialdehyde (MDA) and total thiol (t-SH) correlated significantly with tHcy (0.388 and 0.478, respectively) content, and there was a significant negative correlation between E2 level and glutathione transferase (GST) activity (−0.425) in HRT group. Superoxide dismutase (SOD) and HDL-C correlated significantly with t-SH level (0.339 and 0.336, respectively) in plasma after HRT.

Conclusion

Our results show that HRT is beneficial in the protection against oxidative damage, and prevents atherosclerotic complications.

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Authors and Affiliations

  1. Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa, 34093, Istanbul, Turkey

    Cahide Gökkuşu & Gülten Tata

  2. Eyup State Hospital, Istanbul, Turkey

    Zeynep Özbek

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  1. Cahide Gökkuşu
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  2. Zeynep Özbek
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Correspondence to Cahide Gökkuşu.

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Gökkuşu, C., Özbek, Z. & Tata, G. Hormone replacement therapy: relation to homocysteine and prooxidant-antioxidant status in healthy postmenopausal women. Arch Gynecol Obstet 285, 733–739 (2012). https://doi.org/10.1007/s00404-011-2051-2

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  • DOI: https://doi.org/10.1007/s00404-011-2051-2

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