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Relapse of a group 4 medulloblastoma after 18 years as proven by histology and DNA methylation profiling

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Abstract

Background

Recent studies on medulloblastomas (MB) suggest that a large fraction of tumors appearing as late recurrence turn out to be secondary malignancies, e.g., malignant gliomas, after thorough molecular investigation.

Results

Here, we report of a patient with a group 4 MB that developed a distant recurrence after more than 18 years. The recurrent tumor was confirmed by histology and genome-wide DNA methylation profiling.

Conclusion

Our case not only illustrates the potential of very late recurrences after seemingly cured group 4 MB, but also illustrates that detailed molecular analyses are indispensable in patients with a history of a previous malignancy.

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Acknowledgements

We thank Anne Reichstein for performing genome-wide DNA methylation profiling.

Author information

The authors declare no competing financial interest. Correspondence and requests for materials should be addressed to Dr. Ulrich Schüller.

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Authors and Affiliations

  1. Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany

    Franz L. Ricklefs, Friederike Fritzsche, Lasse Dührsen, Manfred Westphal & Tobias Martens

  2. Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany

    Beate Winkler, Barbara Meissner, Stefan Rutkowski & Ulrich Schüller

  3. Department of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany

    Ulrich Schüller

  4. Research Institute Children’s Cancer Center Hamburg, Martinistrasse 52, N63 (HPI), D-20251, Hamburg, Germany

    Ulrich Schüller

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  1. Franz L. Ricklefs
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  2. Friederike Fritzsche
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  9. Ulrich Schüller
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Correspondence to Ulrich Schüller.

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US was supported by the Fördergemeinschaft Kinderkrebszentrum Hamburg.

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Ricklefs, F.L., Fritzsche, F., Winkler, B. et al. Relapse of a group 4 medulloblastoma after 18 years as proven by histology and DNA methylation profiling. Childs Nerv Syst 35, 1029–1033 (2019). https://doi.org/10.1007/s00381-019-04086-3

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  • DOI: https://doi.org/10.1007/s00381-019-04086-3

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