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Ectopic recurrence of pediatric craniopharyngiomas after gross total resection: a report of two cases and a review of the literature

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Abstract

Introduction

Ectopic recurrent craniopharyngioma is rare. We reported two pediatric cases and reviewed the related literature.

Method

We retrospectively studied 177 craniopharyngioma cases treated by the senior author (Yuan X) between years 2003 and 2013. Two ectopic recurrent craniopharyngiomas were identified. One was discovered under the right frontal lobe and the other was found in the fourth ventricle. Both patients underwent a second radical resection without complications. Then we conducted an extensive review of peer-reviewed, English-language literatures in the US National Library of Medicine, focusing on the treatment modalities, recurrent sites, and clinical outcomes.

Results

Sixty ectopic recurrent tumors have been reported so far (including this study). Thirty-three tumors were located in the previous surgical corridors and 27 were disseminated along the cerebrospinal fluid pathway. All recurrent tumors were surgically removed. The gross total resection (GTR) rates were 87 and 63 %, respectively.

Conclusion

The natural course of recurrent ectopic craniopharyngiomas is progressive. GTR is the treatment of choice. Regular follow-ups are strongly recommended to detect any further recurrence.

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Abbreviations

GTR:

Gross total resection

CSF:

Cerebral spinal fluid

MRI:

Magnetic resonance imaging

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Authors and Affiliations

  1. The Institute of Skull Base Surgery and Neuro-oncology at Hunan, Neurosurgery Institute of Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, People’s Republic of China

    Cheng-Yuan Feng, Jian Yuan & Xianrui Yuan

  2. Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

    Can Du, Cheng-Yuan Feng, Jian Yuan & Xianrui Yuan

Authors
  1. Can Du
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  2. Cheng-Yuan Feng
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  3. Jian Yuan
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  4. Xianrui Yuan
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Correspondence to Xianrui Yuan.

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Du, C., Feng, CY., Yuan, J. et al. Ectopic recurrence of pediatric craniopharyngiomas after gross total resection: a report of two cases and a review of the literature. Childs Nerv Syst 32, 1523–1529 (2016). https://doi.org/10.1007/s00381-016-3050-1

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  • DOI: https://doi.org/10.1007/s00381-016-3050-1

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