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Steady-state B-type natriuretic peptide levels in patients with atrial fibrillation of various clinical backgrounds

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Abstract

B-type natriuretic peptide level is increased in patients with atrial fibrillation. The aim of the present study was to present the distribution of steady-state B-type natriuretic peptide levels of various clinical backgrounds and to elucidate the usefulness of measuring them in patients with atrial fibrillation. B-type natriuretic peptide was measured in stable conditions in patients with atrial fibrillation (74 ± 10 y/o, n = 473). The average B-type natriuretic peptide level was 161 ± 202 (median 101) pg/ml. Multiple regression analysis showed that age, left ventricular ejection fraction, left atrial diameter, structural heart disease, chronic atrial fibrillation, and heart failure symptoms were independently associated with elevated B-type natriuretic peptide levels. However, in chronic atrial fibrillation patients without structural heart disease, B-type natriuretic peptide levels did not differ between those with and without heart failure symptoms. Notably, B-type natriuretic peptide levels were high (≥150 pg/ml) in 41% of asymptomatic chronic atrial fibrillation without structural heart disease. Steady-state B-type natriuretic peptide levels of various clinical backgrounds were presented. Contributions of BNP elevation by clinical variables were somewhat different in different population. B-type natriuretic peptide was elevated in substantial percentage of asymptomatic chronic atrial fibrillation even without structural heart disease.

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Authors and Affiliations

  1. Division of Cardiology, Ueki Hospital, Iwano 285-29, Ueki, Kumamoto, 861-0136, Japan

    Tsuneaki Sadanaga

  2. Saiseikai Central Hospital, Tokyo, Japan

    Hideo Mitamura

  3. Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan

    Shun Kohsaka

  4. International University of Health and Welfare, Mita Hospital, Tokyo, Japan

    Satoshi Ogawa

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  1. Tsuneaki Sadanaga
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  2. Hideo Mitamura
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  3. Shun Kohsaka
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  4. Satoshi Ogawa
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Correspondence to Tsuneaki Sadanaga.

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Sadanaga, T., Mitamura, H., Kohsaka, S. et al. Steady-state B-type natriuretic peptide levels in patients with atrial fibrillation of various clinical backgrounds. Heart Vessels 27, 280–286 (2012). https://doi.org/10.1007/s00380-011-0151-3

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  • DOI: https://doi.org/10.1007/s00380-011-0151-3

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