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In-depth metabolic phenotyping of genetically engineered mouse models in obesity and diabetes

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Abstract

The world-wide prevalence of obesity and diabetes has increased sharply during the last two decades. Accordingly, the metabolic phenotyping of genetically engineered mouse models is critical for evaluating the functional roles of target genes in obesity and diabetes, and for developing new therapeutic targets. In this review, we discuss the practical meaning of metabolic phenotyping, the strategy of choosing appropriate tests, and considerations when designing and performing metabolic phenotyping in mice.

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Acknowledgments

This was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (#2013M3A9D5072563) and the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Korea (#A102060).

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  1. Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Yeonsu-Gu, Songdo-Dong 7-45, Incheon, 406-840, Korea

    Hui-Young Lee, Kyeong-Hoon Jeong & Cheol Soo Choi

  2. Endocrinology, Internal Medicine, Gachon University Gil Medical Center, Namdong-Gu, Guwol-Dong 1198, Incheon, 405-760, Korea

    Cheol Soo Choi

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Lee, HY., Jeong, KH., Choi, C.S. et al. In-depth metabolic phenotyping of genetically engineered mouse models in obesity and diabetes. Mamm Genome 25, 508–521 (2014). https://doi.org/10.1007/s00335-014-9520-4

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