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Patient and physician perspectives on the impact of health-related quality of life in Mexican patients with ANCA-associated vasculitis

  • Observational Research
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Abstract

The objective of this study is to describe aspects of health-related quality of life (HRQOL) in Mexican patients with antineutrophil cytoplasmic-associated vasculitis (AAV). Cross-sectional comparison study includes patients with established AAV and a comparison group with rheumatoid arthritis (RA), chronic kidney disease (CKD), and healthy subjects. Variables considered were: socio-demographic data, comorbidities, laboratory, disease activity, damage, and Physician’s and Patient’s Global Assessment (PhGA and PtGA). The following measurements were done: Pittsburg sleep quality index, Multidimesional Fatigue Inventory (MFI-20), Hospital Anxiety and Depression Scale, Short Form 36 questionnaire (SF-36), and Health Assessment Questionnaire. 60 patients with AAV were included, median age 54 years, and 60% female. Significant differences were found only in the bodily pain domain of the SF-36 (p = 0.01). Aspects of disease relevant for AAV patients were: fatigue and lack of energy; visual abnormalities; neuropathy; renal impairment; arthritis, and sinusitis. Greater total score on MFI-20 (p < 0.001) and worse PtGA (p = 0.01) were associated with worse physical health. Higher PhGA values were associated with worse physical quality of life (p = 0.01). Greater fatigue score (p = 0.002), greater anxiety-depression score (p = 0.005), and worse PtGA (p = 0.01) were associated with worse mental health quality of life. No differences were found in prevalence of sleep impairment, anxiety, depression, or disability between groups. AAV patients experienced more general and physical fatigue (p < 0.0001), and reduced activity (p = 0.01) than healthy subjects, but similar to RA and CKD patients. Vasculitis has negative effects on patients’ physical and mental HRQOL.

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Acknowledgements

The authors would like to thank Irazú Contreras Yáñez for her valuable help in the scoring and interpretation of the SF-36 and HAQ-DI scales.

Author information

Authors and Affiliations

  1. Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Andrea Hinojosa-Azaola & Ariadna Jiménez-González

  2. Department of Neurology and Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15, Col. Sección XVI, Tlalpan, Mexico City, CP 14000, Mexico

    Natasha Alcocer-Castillejos

Authors
  1. Andrea Hinojosa-Azaola
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  2. Ariadna Jiménez-González
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  3. Natasha Alcocer-Castillejos
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Contributions

AHA and NAC designed the study; AHA, AJG, and NAC participated in acquisition of data; AHA, AJG, and NAC analyzed and interpreted data; AHA and NAC drafted the manuscript; AHA, AJG, and NAC revised the manuscript.

Corresponding author

Correspondence to Natasha Alcocer-Castillejos.

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The authors declare no conflicts of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Electronic supplementary material

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296_2017_3904_MOESM1_ESM.docx

Online 1. STROBE Statement. Online Resource 2. AAV patients with and without sleep disorder. Online Resource 3. AAV patients with and without depression or anxiety (DOCX 145 KB)

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Hinojosa-Azaola, A., Jiménez-González, A. & Alcocer-Castillejos, N. Patient and physician perspectives on the impact of health-related quality of life in Mexican patients with ANCA-associated vasculitis. Rheumatol Int 38, 631–640 (2018). https://doi.org/10.1007/s00296-017-3904-1

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  • DOI: https://doi.org/10.1007/s00296-017-3904-1

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