Skip to main content

Advertisement

SpringerLink
Log in

The vasoactive intestinal polypeptide (VIP) levels at the patients with ankylosing spondylitis and its association with inflammation markers

  • Original Article
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

Vasoactive intestinal polypeptide (VIP) is a neuropeptide from secretin/glukagon family. Recently, the importance of VIP is becoming more evident, and it is thought that VIP is playing an important regulatory role between neuroendocrine-immune-gastrointestinal systems. In this study, we have tried to evaluate the potential role of VIP in patients with ankylosing spondylitis (AS). In this study, 40 patients (30 male and 10 female) with AS and 40 healthy controls were included. X-ray examinations and scoring of sacroiliac joints of the patients with AS were done according to 1984 Modified New York Criteria for AS. All patients have been assessed with Bath Ankylosing Spondylitis Disease Activity Index. Platelet counts were significantly higher in study group (P < 0.05) in contrast to levels of the hemoglobin. The mean VIP levels were 4.2 ± 1.8 (pg/mL) for study group and 2.8 ± 0.8 (pg/mL) for controls. These results were statistically significant (P < 0.05). There was not any correlation between plasma VIP levels with CRP, ESR, Hb, BASDAI results and radiological scoring of the patients (P > 0.05) in contrast to our expectations. However, platelet counts and VIP levels were correlated significantly (P = 0.03). Our data demonstrate that VIP tended to be high in patients with AS when compared with healthy subjects and correlated with platelet counts significantly, for the first time at the literature. According to this study, VIP may have potential role in the pathogenesis of AS, and it is a potential candidate for many kinds of therapies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Mielants H, De Vos M, Cuvelier C, Veys EM (1996) The role of gut inflammation in the pathogenesis of spondyloarthropathies. Acta Clin Belg 51(5):340–349

    PubMed  CAS  Google Scholar 

  2. Neunlist M, Van Landeghem L, Bourreille A, Savidge T (2008) Symposium, Neuro-glial crosstalk in inflammatory bowel disease. J Intern Med 263(6):577–583

    Article  PubMed  CAS  Google Scholar 

  3. Nguyen TT, Krco CJ, Gores A, Go VL (1987) Analysis of the immunomodulatory properties of the secretin-glucagon family of peptides on mouse lymphoid cell functions and the demonstration of specific receptors on T cells. Immunol Invest 16(7):555–577

    Article  PubMed  CAS  Google Scholar 

  4. Van der Linden S, Valkenburg HA, Cats A (1984) Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modification of the New York criteria. Arthritis Rheum 27:361–368

    Article  PubMed  Google Scholar 

  5. Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A (1994) A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 21(12):2286–2291

    PubMed  CAS  Google Scholar 

  6. Said SI, Mutt V (1970) Polypeptide with broad biological activity: Isolation from small intestine. Science 169:12–17

    Article  Google Scholar 

  7. Said SI, Mutt V (1970) Potent peripheral and splanchnic vasodilator peptide from normal gut. Nature 225:863

    Article  PubMed  CAS  Google Scholar 

  8. Dockray GJ (1994) Vasoactive Intestinal Polypeptide and related Peptides. In: Walsh JH, Dockray GJ (eds) Gut Hormones: Biochemistry and Physiology, 1st edn. Raven Press, Ltd, New York, p 447

    Google Scholar 

  9. Paladini F, Cocco E, Cauli A, Cascino I, Vacca A, Belfiore F, Fiorillo MT, Mathieu A, Sorrentino R (2008) A functional polymorphism of the vasoactive intestinal peptide receptor 1 gene correlates with the presence of HLA-B*2705 in Sardinia. Genes and Immunity 9:659–667

    Article  PubMed  CAS  Google Scholar 

  10. Pozo D, Delgado M (2004) The many faces of VIP in neuroimmunology: a cytokine rather a neuropeptide? FASEB J 18:1325

    Article  PubMed  CAS  Google Scholar 

  11. Delgado M, Pozo D, Ganea D (2004) The significance of vasoactive intestinal peptide in immunomodulation. Pharmacol Rev 56:249

    Article  PubMed  CAS  Google Scholar 

  12. Wang F, Yan CG, Xiang HY, Xing T, Wang NS (2008) The significance of platelet activation in ankylosing spondylitis. Clin Rheumatol 27(6):767–769 (Epub 2008 Feb 5)

    Article  PubMed  Google Scholar 

  13. Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA, Kiraz S, Ertenli I, Calguneri M (2008) Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine. 75(3):291–294

    Article  PubMed  Google Scholar 

  14. Ekblad E, Winther C, Ekman R et al (1987) Projections of peptide-containing neurons in rat small intestine. Neuroscience 20:169

    Article  PubMed  CAS  Google Scholar 

  15. Porter AJ, Wattchow DA, Brookes SJ, Costa M (1999) Projections of nitric oxide synthase and vasoactive intestinal polypeptide-reactive submucosal neurons in the human colon. J Gastroenterol Hepatol 14:1180

    Article  PubMed  CAS  Google Scholar 

  16. Maggi CA, Giachetti A, Dey RD, Said SI (1995) Neuropeptides as regulators of airway function: vasoactive intestinal peptide and the tachykinins. Physiol Rev

  17. Adeghate E (1999) Distribution of calcitonin-gene-related peptide, neuropeptide-Y, vasoactive intestinal polypeptide, cholecystokinin-8, substance P and islet peptides in the pancreas of normal and diabetic rats. Neuropeptides 33:227

    Article  PubMed  CAS  Google Scholar 

  18. Kitanishi T, Suzuki M, Kitano H et al (1998) Immunohistochemical detection of vasoactive intestinal polypeptide (VIP) and the VIP receptor in the rat inner ear. Acta Otolaryngol Suppl 539:52

    Article  PubMed  CAS  Google Scholar 

  19. Delgado M, Robledo G, Rueda B, Varela N, O’Valle F, Hernandez-Cortes P, Caro M, Orozco G, Gonzalez-Rey E, Martin J (2008) Genetic association of vasoactive intestinal peptide receptor with rheumatoid arthritis: altered expression and signal in immune cells. Arthritis Rheum 58(4):1010–1019

    Article  PubMed  CAS  Google Scholar 

  20. Palsson OS, Morteau O, Bozymski EM et al (2004) Elevated vasoactive intestinal peptide concentrations in patients with irritable bowel syndrome. Dig Dis Sci 49:1236

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Internal Medicine, GATA Haydarpasa Training Hospital, Istanbul, Turkey

    Selim Nalbant, Eylem Cagıltay, Burak Sahan, Hakan M. Terekeci & Cagatay Oktenli

Authors
  1. Selim Nalbant
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eylem Cagıltay
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Burak Sahan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hakan M. Terekeci
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Cagatay Oktenli
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eylem Cagıltay.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nalbant, S., Cagıltay, E., Sahan, B. et al. The vasoactive intestinal polypeptide (VIP) levels at the patients with ankylosing spondylitis and its association with inflammation markers. Rheumatol Int 31, 1143–1146 (2011). https://doi.org/10.1007/s00296-010-1417-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-010-1417-2

Keywords

Search

Navigation