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Pulmonary and psoas muscle nocardiosis in a patient with lupus nephritis: a case report and review of the literature

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Abstract

The incidence of nocardiosis is increasing with the expansion of immunosuppressive therapy and improvement of laboratory diagnostic methods. Nocardiosis could be fatal in the compromised host. Some Nocardia species are known to be multi-drug resistant. Thus, early recognition and identification of Nocardia species are important for patient treatment and outcome. Recently, we treated a patient with pulmonary and psoas muscle nocardiosis in a woman taking prednisolone for lupus nephritis; the isolated organism was Nocardia farcinica identified by polymerase chain reaction-restriction fragment length polymorphism testing.

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References

  1. Saubolle MA, Sussland D (2003) Nocardiosis: review of clinical and laboratory experience. J Clin Microbiol 41:4497–4501

    Article  PubMed  Google Scholar 

  2. Euzeby JP (2009) List of prokaryotic names with standing in nomenclature—genus Nocardia. http://www.bacterio.cict.fr/n/nocardia.html

  3. Kofteridis D, Mantadakis E, Mixaki I, Stefanidou M, Maraki S, Alexandrakis M, Samonis G (2005) Primary cutaneous nocardiosis in 2 patients on immunosuppressants. Scand J Infect Dis 37:507–510

    Article  PubMed  Google Scholar 

  4. Brown-Elliott BA, Brown JM, Conville PS, Wallace RJ Jr (2006) Clinical and laboratory features of the Nocardia spp. based on current molecular taxonomy. Clin Microbiol Rev 19:259–282

    Article  PubMed  CAS  Google Scholar 

  5. Agterof MJ, van der Bruggen T, Tersmette M, ter Borg EJ, van den Bosch JM, Biesma DH (2007) Nocardiosis: a case series and a mini review of clinical and microbiological features. Neth J Med 65:199–202

    PubMed  CAS  Google Scholar 

  6. Kageyama A, Yazawa K, Ishikawa J, Hotta K, Nishimura K, Mikami Y (2004) Nocardial infections in Japan from 1992 to 2001, including the first report of infection by Nocardia transvalensis. Eur J Epidemiol 19:383–389

    Article  PubMed  CAS  Google Scholar 

  7. Pintado V, Gómez-Mampaso E, Fortún J, Meseguer MA, Cobo J, Navas E, Quereda C, Martín-Dávila P, Moreno S (2002) Infection with Nocardia species: clinical spectrum of disease and species distribution in Madrid, Spain, 1978–2001. Infection 30:338–340

    Article  PubMed  CAS  Google Scholar 

  8. Castro JG, Espinoza L (2007) Nocardia species infections in a large county hospital in Miami: 6 years experience. J Infect 54:358–361

    Article  PubMed  Google Scholar 

  9. Chedid MB, Chedid MF, Porto NS, Severo CB, Severo LC (2007) Nocardial infections: report of 22 cases. Rev Inst Med Trop Sao Paulo 49:239–246

    Article  PubMed  Google Scholar 

  10. Boiron P, Provost F, Chevrier G, Dupont B (1992) Review of nocardial infections in France 1987 to 1990. Eur J Clin Microbiol Infect Dis 11:709–714

    Article  PubMed  CAS  Google Scholar 

  11. Peleg AY, Husain S, Qureshi ZA, Silveira FP, Sarumi M, Shutt KA, Kwak EJ, Paterson DL (2007) Risk factors, clinical characteristics, and outcome of Nocardia infection in organ transplant recipients: a matched case-control study. Clin Infect Dis 44:1307–1314

    Article  PubMed  Google Scholar 

  12. Kontoyiannis DP, Ruoff K, Hooper DC (1998) Nocardia bacteremia. Report of 4 cases and review of the literature. Medicine (Baltimore) 77:255–267

    Article  CAS  Google Scholar 

  13. Yildiz O, Alp E, Tokgoz B, Tucer B, Aygen B, Sumerkan B, Couble A, Boiron P, Doganay M (2005) Nocardiosis in a teaching hospital in the Central Anatolia region of Turkey: treatment and outcome. Clin Microbiol Infect 11:495–499

    Article  PubMed  CAS  Google Scholar 

  14. Schaal KP, Lee HJ (1992) Actinomycete infections in humans—a review. Gene 115:201–211

    Article  PubMed  CAS  Google Scholar 

  15. Devi KR, Singh LR, Devi NT, Singh NS (2007) Subcutaneous nocardial abscess in a post-renal transplant patient. Indian J Med Microbiol 25:279–281

    Article  PubMed  CAS  Google Scholar 

  16. Farina C, Andrini L, Bruno G, Sarti M, Tripodi MF, Utili R, Boiron P (2007) Nocardia brasiliensis in Italy: a nine-year experience. Scand J Infect Dis 39:969–974

    Article  PubMed  Google Scholar 

  17. Nizam I, Kohan L, Kerr D (2007) Nocardia nova septic arthritis following total knee replacement: a case report. J Orthop Surg (Hong Kong) 15:390–392

    CAS  Google Scholar 

  18. Shimamoto H, Inaba Y, Yamaura H, Sato Y, Kamiya M, Miyazaki M, Arai Y, Horio Y (2007) Chest wall dissemination of nocardiosis after percutaneous transthoracic needle biopsy. Cardiovasc Interv Radiol 30:797–799

    Article  Google Scholar 

  19. Yildiz O, Doganay M (2006) Actinomycoses and Nocardia pulmonary infections. Curr Opin Pulm Med 12:228–234

    Article  PubMed  Google Scholar 

  20. Beaman BL, Beaman L (1994) Nocardia species: host-parasite relationships. Clin Microbiol Rev 7:213–264

    PubMed  CAS  Google Scholar 

  21. Glupczynski Y, Berhin C, Janssens M, Wauters G (2006) Determination of antimicrobial susceptibility patterns of Nocardia spp. from clinical specimens by Etest. Clin Microbiol Infect 12:905–912

    Article  PubMed  CAS  Google Scholar 

  22. Wallace RJ Jr, Tsukamura M, Brown BA, Brown J, Steingrube VA, Zhang YS, Nash DR (1990) Cefotaxime-resistant Nocardia asteroides strains are isolates of the controversial species Nocardia farcinica. J Clin Microbiol 28:2726–2732

    PubMed  Google Scholar 

  23. Steingrube VA, Brown BA, Gibson JL, Wilson RW, Brown J, Blacklock Z, Jost K, Locke S, Ulrich RF, Wallace RJ Jr (1995) DNA amplification and restriction endonuclease analysis for differentiation of 12 species and taxa of Nocardia, including recognition of four new taxa within the Nocardia asteroides complex. J Clin Microbiol 33:3096–3101

    PubMed  CAS  Google Scholar 

  24. Lee H, Park HJ, Cho SN, Bai GH, Kim SJ (2000) Species identification of mycobacteria by PCR-restriction fragment length polymorphism of the rpoB gene. J Clin Microbiol 38:2966–2971

    PubMed  CAS  Google Scholar 

  25. Cuchacovich R, Gedalia A (2009) Pathophysiology and clinical spectrum of infections in systemic lupus erythematosus. Rheum Dis Clin N Am 35:75–93

    Article  Google Scholar 

  26. Park K, Chong Y, Lee SY (1987) Pulmonary nocardiosis in a renal transplant patient. Yonsei Med J 28:157–161

    PubMed  CAS  Google Scholar 

  27. Park ES, Lee KY, Shim SI, Kim SM (1988) Systemic nocardiosis: an autopsy case. Korean J Pathol 22:131–137

    Google Scholar 

  28. Sung YS, Kim SJ, Park SP, Kang JK, Doh JO (1989) Cerebellar nocardiosis: case report. J Korean Neurosurg Soc 18:961–965

    Google Scholar 

  29. Han CY, Nam GY, Park SB, Kim HC (1992) A case of pulmonary nocardiosis in a renal transplant patient. Korean J Med 43:410–415

    Google Scholar 

  30. Kim JH, Yoon KH, Yoo JH, Kang HM, Suh JT (1992) A case of nocardiosis. Tuberc Respir Dis 39:355–360

    Google Scholar 

  31. Min CK, Jin DC, Yoon SA, Kim YS, Yoon YS, Bang BK (1992) A nocardial infection in the renal transplant recipient. J Korean Soc Transplant 6:55–59

    Google Scholar 

  32. Yim H, Park KH (1995) Pulmonary nocardiosis diagnosed by fine needle aspiration: a case report. Korean J Cytopathol 6:169–173

    Google Scholar 

  33. Kim IT, Lee CK, Kim YK, Lee KN (1997) Nocardia asteroides complex isolated from cerebrospinal fluid and surgical wound site: three case reports. Korean J Clin Pathol 17:296–302

    Google Scholar 

  34. Huh D, Lee JM, Jung YS, Jang ID, Kam BK, Kim MS, Kim JK, Lee SR, Lee JS (1997) Two cases of nocardial infection in the renal transplant recipient. J Korean Soc Transplant 11:131–136

    Google Scholar 

  35. Park JH, An JH, Lee BH, Min CH, Kang ET, Yu SH (1997) A case of nocardial peritonitis in a patient on continuous ambulatory peritoneal dialysis. Korean J Nephrol 16:836–839

    Google Scholar 

  36. Choi JH, Choi SM, Lee IS, Lee JW, Shin WS, Min WS, Kim CC, Kim DJ (1998) A case of nocardiosis after bone marrow transplantation. Korean J Infect Dis 30:300–303

    Google Scholar 

  37. Shin KH, Lee WS, Son YK, Lee K, Chong Y (1998) Nocardia osteomyelitis in a pachymeningitis patient: an example of a difficult case to treat with antimicrobial agents. Yonsei Med J 39:604–610

    PubMed  CAS  Google Scholar 

  38. Kwun WH, Suh BY, Kwun KB, Do JY, Park TC (1998) Neurologic complications in kidney transplant recipients. J Korean Soc Transplant 12:327–337

    Google Scholar 

  39. Lee S, Koh DK, Yeon HC, Cho MH, Kim JS, Lee YC, Jung KS, Chae DW, Kim HJ, Han SW, Nam ES, Kim MH, Kim ST, Choi CS (1999) Pulmonary infection after kidney transplantation. J Korean Soc Transplant 13:311–322

    Google Scholar 

  40. Yang CW, Kim YS, Bang BK, Park JH, Chae EY, Kim YK, Park EJ (1999) A case of empyema thorax and intraabdominal abscess caused by nocardiac species. Korean J Nephrol 18:825–829

    Google Scholar 

  41. Jung HJ, Kim BD, Lee EY, Cho KH, Bae SW, Park JB, Kim YG, Do JY, Yoon KW (1999) A case of disseminated nocardiosis in kidney transplant recipient. Korean J Nephrol 18:634–638

    Google Scholar 

  42. Cheong JY, Ko YW, Chong SY, Chong YS, Min YH, Hahn JS (1999) A case of nocardiosis in patient with chronic lymphocytic leukemia. Korean J Hematol 34:137–142

    Google Scholar 

  43. Kim CY, Kim TH, Lee WS, Lee AY (2002) Reactive cutaneous cytophagocytosis in nocardiosis. J Korean Med Sci 17:279–282

    PubMed  Google Scholar 

  44. Kim TH, Kim SC, Sohn JH, Sung HS, Kim MN, Han DJ (2001) Nocardiosis following renal transplantation. J Korean Soc Transplant 15:208–216

    Google Scholar 

  45. Ahn YS, Lee SM, Joo JE (2002) Alcoholic liver cirrhosis with multiple pulmonary consolidations. Tuberc Respir Dis 53:79–84

    Google Scholar 

  46. Kwon EH, Lee NY, Song KE, Suh JS, Lee WK (2002) A case of Nocardia asteroides isolated from subcutaneous abscess in a pneumonic patient with a rejected transplant kidney. Korean J Clin Pathol 22:101–104

    Google Scholar 

  47. Lee JS, Lee YH, Cho SJ, Ji JD, Song GG (2002) A nocardial infection in a patient with systemic lupus erythematosus. Korean J Med 62:100–103

    Google Scholar 

  48. Park HR, Youn YH, Sohn JH (2003) Case report: endogenous nocardial endophthalmitis in a renal transplant recipient. J Korean Ophthalmol Soc 44:998–1001

    Google Scholar 

  49. Lee SY, Oh YM, Lim CM, Lee SD, Koh YS, Kim WS, Kim DS, Kim WD, Shim TS (2004) A case of pulmonary nocardiosis in the patient with Cushing’s disease. Tuberc Respir Dis 57:61–65

    Google Scholar 

  50. Chang SJ, Lee KN, Sung YK, Lee HS, Uhm WS, Kim TH, Jun JB, Pai HJ, Bae SC, Jeon SC, Yoo DH (2005) Pulmonary nocardiosis in a patient with lupus nephritis. J Korean Rheum Assoc 12:47–51

    CAS  Google Scholar 

  51. Kim SM, Kim JH, Park MJ, Park CS, Jun JM, Oh HJ, Park YK, Sin YH, Kim JK, Park JI (2005) A case of nocardiosis with CMV (cytomegalovirus) infection after third renal transplantation in China. J Korean Soc Transplant 19:63–68

    Google Scholar 

  52. Choe WH, Kang JO, Pai HJ, Choi TY (2005) A case of Nocardia asteroides type I induced pneumonia. Korean J Lab Med 25:324–328

    Google Scholar 

  53. Baek YH, Kim YJ, Lee HH, Youm JY, Kwon OW, Kim JH, Kim SH, Kang CN, Choi TY, Bae SC (2006) A case of intramuscular abscess caused by Nocardia farcinica in a patient with lupus nephritis concurrent with pulmonary tuberculosis. J Korean Rheum Assoc 13:327–332

    Google Scholar 

  54. Chang WI, Kim SJ, Kim YC, Kwon KT, Oh WS, Peck KR, Song JH (2007) A case of primary cutaneous nocardiosis in a patient with lung cancer. Korean J Med 73:342–345

    Google Scholar 

  55. Park KH, Ko SY, Oh R, Kim T, Cho OH, Kim YS, Woo JH, Han DJ, Sung HS, Kim MN (2008) A case of lung abscess caused by Nocardia elegans in a kidney transplantation recipient. Infect Chemother 40:116–120

    Article  Google Scholar 

  56. NCCLS (2003) Susceptibility testing of mycobacteria, nocardiae, and other aerobic actinomycetes; Approved standard. NCCLS document M24-A

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The authors have no conflict of interest.

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Authors and Affiliations

  1. Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Korea University Guro Hospital, 97 Gurodong-Gil, Guro-Gu, Seoul, 152-703, Republic of Korea

    Ji Yun Noh, Hee Jin Cheong, Jung Yeon Heo, Won Suk Choi, Yu Mi Jo, Joon Young Song & Woo Joo Kim

  2. Department of Laboratory Medicine, Korea University College of Medicine, Seoul, Republic of Korea

    Chang Kyu Lee & Sung Il Kim

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  1. Ji Yun Noh
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  2. Hee Jin Cheong
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Correspondence to Hee Jin Cheong.

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Noh, J.Y., Cheong, H.J., Heo, J.Y. et al. Pulmonary and psoas muscle nocardiosis in a patient with lupus nephritis: a case report and review of the literature. Rheumatol Int 31, 929–936 (2011). https://doi.org/10.1007/s00296-009-1211-1

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  • DOI: https://doi.org/10.1007/s00296-009-1211-1

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