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Lupus patients with pulmonary involvement have a pro-inflammatory cytokines profile

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Abstract

Objectives

The literature on cytokine response in systemic lupus erythematosus (SLE) is confusing. It is possible that different disease phenotypes have different cytokine profiles. Our aim was to examine the levels of selected pro-inflammatory and anti-inflammatory cytokines in SLE patients with and without pulmonary involvement.

Methods and subjects

Patients with SLE were interviewed and were subjected to the pulmonary function test and high-resolution computed tomography studies. Serum levels of interleukin (IL)-6, IL-8, IL-10, Il-12, interferon (IFN) γ, and tumor necrosis factor (TNF) α were estimated by enzyme-linked immunosorbent assay.

Results

Forty-nine of the 61 SLE patients had pulmonary involvement. Median levels of IL-8, IFNγ, and TNFα were significantly higher in the pulmonary group as compared to the non-pulmonary group (p = 0.027, 0.027 and 0.002, respectively). Ratios of pro-inflammatory cytokines to anti-inflammatory cytokines were higher in the pulmonary group as compared to the non-pulmonary group as well as in the pulmonary restrictive subgroup compared to the obstructive subgroup.

Conclusion

Lupus patients with pulmonary involvement have a stronger pro-inflammatory cytokine bias than those without pulmonary involvement.

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Acknowledgments

We would like to thank Mrs. Ajita Suresh, and Dr. Fawaz Azizieh for their technical assistance.

Author information

Author notes

  1. Adeebah Al-Herz

    Present address: Department of Medicine, Al-Amiri Hospital, Ministry of Health, Safat, Kuwait

Authors and Affiliations

  1. Department of Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat, 13110, Kuwait

    Sana Al-Mutairi & Adel Al-Awadhi

  2. Department of Microbiology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat, 13110, Kuwait

    Raj Raghupathy & Parvez Rawoot

  3. Department of Radiology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat, 13110, Kuwait

    Hanaa Al-Khawari

  4. Department of Radiology, Al-Amiri Hospital, Ministry of Health, Safat, Kuwait

    Prio Sada

  5. Department of Medicine, Mubarak Al-Khabeer Hospital, Ministry of Health, Safat, Kuwait

    Adeebah Al-Herz

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  1. Sana Al-Mutairi
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Correspondence to Sana Al-Mutairi.

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Al-Mutairi, S., Al-Awadhi, A., Raghupathy, R. et al. Lupus patients with pulmonary involvement have a pro-inflammatory cytokines profile. Rheumatol Int 27, 621–630 (2007). https://doi.org/10.1007/s00296-006-0268-3

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  • DOI: https://doi.org/10.1007/s00296-006-0268-3

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