Abstract
Objective
The aim of this study was to determine the prevalence of joint pain and arthritis in renal transplant recipients and to investigate relationships with various laboratory and clinical parameters.
Methods
Eighty-two patients who underwent renal transplantation (RT) had joint examinations and reportedv by questionnaire on levels of joint pain and arthritis. Each individual was then followed by the rheumatology department for 1 year, with joint examination and laboratory tests every 3 months.
Results
Thirty-one of 82 patients (37.8%) complained of joint pain before RT, of whom seven reported pain continuing after the operation. Seventeen of the 82 (20.7%) began to suffer joint pain after RT. Six (7.3%) and three (3.7%) of the 82 patients, respectively, developed arthritis before and after transplantation.
Conclusion
The study showed that joint pain is common before and after RT. In renal transplant recipients, joint pain significantly correlated with serum cyclosporine levels higher than 200 ng/ml.
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References
Kessler BM, Netter P, Azoulay E, Mayeux D, Pere P, Gaucher A (1992) Dialysis-associated arthropathy: a multicentre survey of 171 patients receiving haemodialysis for over 10 years. Br J Rheumatol 31:157–162
Bardin T, Lebail-Darne JL, Zingraff J, Laredo JD, Voisin MC, Kreis H et al (1995) Dialysis arthropathy: outcome after renal transplantation. Am J Med 99:243–248
Marcen R, Gallego N, Orofino L, Gamez C, Estepa MR, Sabater J et al (1995) Impairment of tubular secretion of urate in renal transplant patients on cyclosporine. Nephron 70:307–313
Carlini RG, Rojas E, Arminio A, Weisinger JR, Bellorin-Font E (1998) What are the bone lesions in patients with more than four years of a functioning renal transplant? Nephrol Dial Transplant 13:103–104
Bailie GR, Eisele G (1990) Cyclosporine-associated arthralgia. Clin Nephrol 33:256–257
Dubost JJ, Fourcade J, Sourbrier M, Ristori JM, Sauvezie B, Deteix P (1997) Epiphyseal pain from cyclosporine in renal transplants. Nephrologie 18:22
Torregrosa JV, Campistol JM, Montesinos M, Fenollosa B, Pons F, Martinez DE, Osaba MJ et al (1995) Factors involved in the loss of bone mineral density after renal transplantation. Transplant Proc 27:224–225
Aroldi A, Tarantino A, Montagnino G et al (1997) Effects of three immunosuppressive regimens on vertebral bone density in renal transplant recipients. Transplant 63:380
Bardin T, Zingraff J, Kuntz D, Drüeke T (1986) Dialysis related amyloidosis. Nephrol Dial Transplant 1:151–154
Jadoul M, Garbar C, Noel H, Sennesael J, Vanholder R, Bernaert P et al (1997) Histological prevalence of β2-microglobulin amyloidosis in hemodialysis: a prospective postmortem study. Kidney Int 51:1928–1932
Van Ypersele de Strihou C, Jadoul M, Malghem L, Maldague B, Jamart J (1991) Effect of hemodialysis membrane and patients' age on signs of dialysis related amyloidosis. Kidney Int 39:1012–1019
Kubo T, Fujioka M, Yamazoe S, Yashimura N, Oka T, Ushijima Y et al (1998) Relationship between steroid dosage and osteonecrosis of the femoral head after renal transplantation as measured by magnetic resonance imaging. Transplant Proc 30:3039–3040
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Kart-Köseoglu, H., Yücel, A.E., Isıklar, I. et al. Joint pain and arthritis in renal transplant recipients and correlation with cyclosporine therapy. Rheumatol Int 23, 159–162 (2003). https://doi.org/10.1007/s00296-002-0283-y
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DOI: https://doi.org/10.1007/s00296-002-0283-y