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Percutaneous Intraductal Radiofrequency Ablation is a Safe Treatment for Malignant Biliary Obstruction: Feasibility and Early Results

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Abstract

Purpose

Previous clinical studies have shown the safety and efficacy of this novel radiofrequency ablation catheter when used for endoscopic palliative procedures. We report a retrospective study with the results of first in man percutaneous intraductal radiofrequency ablation in patients with malignant biliary obstruction.

Methods

Thirty-nine patients with inoperable malignant biliary obstruction were included. These patients underwent intraductal biliary radiofrequency ablation of their malignant biliary strictures following external biliary decompression with an internal-external biliary drainage. Following ablation, they had a metal stent inserted.

Results

Following this intervention, there were no 30-day mortality, hemorrhage, bile duct perforation, bile leak, or pancreatitis. Of the 39 patients, 28 are alive and 10 patients are dead with a median survival of 89.5 (range 14–260) days and median stent patency of 84.5 (range 14–260) days. One patient was lost to follow-up. All but one patient had their stent patent at the time of last follow-up or death. One patient with stent blockage at 42 days postprocedure underwent percutaneous transhepatic drain insertion and restenting. Among the patients who are alive (n = 28) the median stent patency was 92 (range 14–260) days, whereas the patients who died (n = 10) had a median stent patency of 62.5 (range 38–210) days.

Conclusions

In this group of patients, it appears that this new approach is feasible and safe. Efficacy remains to be proven in future, randomized, prospective studies.

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Acknowledgement

This study was supported by the Czech Republic Ministry of Health’s Departmental Research and Development Programme NT11128.

Conflict of interest

Joanna Nicholls and Nagy Habib are shareholders and directors of EMcision Limited; Robert Dickinson is a board member of EMcision Limited, the company that developed The Habib™ Percutaneous Endobiliary RF ablation catheter. None of the other authors have a conflict of interest or a financial disclosure to declare.

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Authors and Affiliations

  1. Department of Radiology, Tbilisi State Medical University, Tbilisi, Georgia

    Malkhaz Mizandari

  2. Department of Surgery, Imperial College, London, Hammersmith Hospital Campus, London, W12 0NN, UK

    Madhava Pai, Feng Xi, Charis Kyriakides, Joanna Nicholls & Nagy Habib

  3. Department of Radiology, University Hospital Brno Bohunice, Jihlavka 20, 63900, Brno, Czech Republic

    Vlastimil Valek & Andrasina Tomas

  4. Department of Radiology, IRCCS Policlinico San Matteo, Pavia, Italy

    Pietro Quaretti

  5. Department of Radiology, Policlinico S. Orsola-Malpighi, University of Bologna, Bologna, Italy

    Rita Golfieri & Cristina Mosconi

  6. Department of Radiology, The 309 Hospital of Chinese PLA, Beijing, China

    Ao Guokun

  7. Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK

    Robert Dickinson

  8. EMcision Limited, London, W12 0HS, UK

    Robert Dickinson, Joanna Nicholls & Nagy Habib

Authors
  1. Malkhaz Mizandari
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  2. Madhava Pai
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  3. Feng Xi
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  4. Vlastimil Valek
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  5. Andrasina Tomas
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  6. Pietro Quaretti
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  7. Rita Golfieri
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  8. Cristina Mosconi
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  9. Ao Guokun
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  10. Charis Kyriakides
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  11. Robert Dickinson
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  12. Joanna Nicholls
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  13. Nagy Habib
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Corresponding author

Correspondence to Nagy Habib.

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Mizandari, M., Pai, M., Xi, F. et al. Percutaneous Intraductal Radiofrequency Ablation is a Safe Treatment for Malignant Biliary Obstruction: Feasibility and Early Results. Cardiovasc Intervent Radiol 36, 814–819 (2013). https://doi.org/10.1007/s00270-012-0529-3

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  • DOI: https://doi.org/10.1007/s00270-012-0529-3

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