Skip to main content
Log in

Diffusion-weighted imaging in hemorrhagic abdominal and pelvic lesions: restricted diffusion can mimic malignancy

  • Pictorial essay
  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

Diffusion-weighted imaging (DWI) is an increasingly utilized sequence in the assessment of abdominal and pelvic lesions. Benign lesions containing hemorrhagic products, with conglomerates of tightly packed blood cells or fibers, can have restricted water diffusion on DWI and apparent diffusion coefficient maps. Such lesions can have restricted diffusion erroneously attributed to malignancy. This review illustrates benign hemorrhagic lesions displaying restricted diffusion, with histopathologic correlation in relevant cases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12

Similar content being viewed by others

References

  1. Morani AC (2013) Abdominal applications of diffusion-weighted magnetic resonance imaging: where do we stand. World J Radiol 5:68. doi:10.4329/wjr.v5.i3.68

    Article  PubMed  PubMed Central  Google Scholar 

  2. Moore WA, Khatri G, Madhuranthakam AJ, Sims RD, Pedrosa I (2014) Added value of diffusion-weighted acquisitions in MRI of the abdomen and pelvis. Am J Roentgenol 202:995–1006. doi:10.2214/AJR.12.9563

    Article  Google Scholar 

  3. Kele PG, van der Jagt EJ (2010) Diffusion weighted imaging in the liver. World J Gastroenterol 16:1567–1576. doi:10.3748/wjg.v16.i13.1567

    Article  PubMed  PubMed Central  Google Scholar 

  4. Whittaker CS, Coady A, Culver L, et al. (2009) Diffusion-weighted MR imaging of female pelvic tumors: a pictorial review. RadioGraphics 29:759–774. doi:10.1148/rg.293085130

    Article  PubMed  Google Scholar 

  5. Feuerlein S, Pauls S, Juchems MS, et al. (2009) Pitfalls in abdominal diffusion-weighted imaging: how predictive is restricted water diffusion for malignancy. Am J Roentgenol 193:1070–1076. doi:10.2214/AJR.08.2093

    Article  Google Scholar 

  6. Qayyum A (2009) Diffusion-weighted imaging in the abdomen and pelvis: concepts and applications. Radiographics 29:1797–1810. doi:10.1148/rg.296095521

    Article  PubMed  Google Scholar 

  7. Koc Z, Erbay G (2014) Optimal b value in diffusion-weighted imaging for differentiation of abdominal lesions. J Magn Reson Imaging 40:559–566. doi:10.1002/jmri.24403

    Article  PubMed  Google Scholar 

  8. Sugita R, Ito K, Fujita N, Takahashi S (2010) Diffusion-weighted MRI in abdominal oncology: clinical applications. World J Gastroenterol 16:832–836. doi:10.3748/wjg.v16.i7.832

    Article  PubMed  PubMed Central  Google Scholar 

  9. Bharwani N, Koh DM (2013) Diffusion-weighted imaging of the liver: an update. Cancer Imaging 13:171–185. doi:10.1102/1470-7330.2013.0019

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  10. Metens T, Ferraresi KF, Farchione A, et al. (2014) Normal hepatic parenchyma visibility and ADC quantification on diffusion-weighted MRI at 3 T: influence of age, gender, and iron content. Eur Radiol 24:3123–3133. doi:10.1007/s00330-014-3353-0

    Article  PubMed  Google Scholar 

  11. Mannelli L, Bhargava P, Osman SF, et al. (2013) Diffusion-weighted imaging of the liver: a comprehensive review. Curr Probl Diagn Radiol 42:77–83. doi:10.1067/j.cpradiol.2012.07.001

    Article  PubMed  Google Scholar 

  12. Herek D, Karabulut N, Kocyıgıt A, Yagcı AB (2016) Evaluation of free breathing versus breath hold diffusion weighted imaging in terms apparent diffusion coefficient (ADC) and signal-to-noise ratio (SNR) values for solid abdominal organs. Pol J Radiol 81:502–506. doi:10.12659/PJR.895868

    Article  PubMed  PubMed Central  Google Scholar 

  13. Rakow-Penner RA, White NS, Parsons JK, et al. (2015) Novel technique for characterizing prostate cancer utilizing MRI restriction spectrum imaging: proof of principle and initial clinical experience with extraprostatic extension. Prostate Cancer Prostatic Dis 18:81–85. doi:10.1038/pcan.2014.50

    Article  PubMed  CAS  Google Scholar 

  14. Brunsing RL, Schenker-Ahmed NM, White NS, et al. (2017) Restriction spectrum imaging: an evolving imaging biomarker in prostate MRI. J Magn Reson Imaging 45:323–336. doi:10.1002/jmri.25419

    Article  PubMed  Google Scholar 

  15. Nougaret S, Tirumani SH, Addley H, et al. (2013) Pearls and pitfalls in MRI of gynecologic malignancy with diffusion-weighted technique. Am J Roentgenol 200:261–276. doi:10.2214/AJR.12.9713

    Article  Google Scholar 

  16. Busard MPH, Mijatovic V, Van Kuijk C, Hompes PGA, Van Waesberghe JHTM (2010) Appearance of abdominal wall endometriosis on MR imaging. Eur Radiol 20:1267–1276. doi:10.1007/s00330-009-1658-1

    Article  PubMed  Google Scholar 

  17. Eid M, Abougabal A (2014) Subtraction images: a really helpful tool in non-vascular MRI. Egypt J Radiol Nucl Med 45:909–919. doi:10.1016/j.ejrnm.2014.04.013

    Article  Google Scholar 

  18. Khedr SA, Kassem HM, Hazzou AM, Awad E, Fouad MM (2013) MRI diffusion-weighted imaging in intracranial hemorrhage (ICH). Egypt J Radiol Nucl Med 44:625–634. doi:10.1016/j.ejrnm.2013.04.010

    Article  Google Scholar 

  19. Kang BK, Na DG, Ryoo JW, et al. (2001) Diffusion-weighted MR imaging of intracerebral hemorrhage. Korean J Radiol 2:183–191. doi:10.3348/kjr.2001.2.4.183

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  20. Bozgeyik Z, Onur MR, Poyraz AK (2013) The role of diffusion weighted magnetic resonance imaging in oncologic settings. Quant Imaging Med Surg 3:269–278. doi:10.3978/j.issn.2223-4292.2013.10.07

    Article  PubMed  PubMed Central  Google Scholar 

  21. Miller FH, Hammond N, Siddiqi AJ, et al. (2010) Utility of diffusion-weighted MRI in distinguishing benign and malignant hepatic lesions. J Magn Reson Imaging 32:138–147. doi:10.1002/jmri.22235

    Article  PubMed  Google Scholar 

  22. Sandrasegaran K, Sundaram CP, Ramaswamy R, et al. (2010) Usefulness of diffusion-weighted imaging in the evaluation of renal masses. Am J Roentgenol 194:438–445. doi:10.2214/AJR.09.3024

    Article  Google Scholar 

  23. Avcu S, Koseoglu MN, Ceylan K, Dbulutand M, Unal O (2011) The value of diffusion-weighted MRI in the diagnosis of malignant and benign urinary bladder lesions. Br J Radiol 84:875–882. doi:10.1259/bjr/30591350

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  24. Emara DMM, Mohamed FSE-D, Abdullah AH, et al. (2014) Is diffusion weighted imaging adding value in diagnosis of focal hepatic lesions? Experience in 50 patients. Alexandria J Med 50:287–301. doi:10.1016/j.ajme.2013.03.012

    Article  Google Scholar 

  25. Casillas VJ, Amendola MA, Gascue A, et al. (2000) Imaging of nontraumatic hemorrhagic hepatic lesions. Radiographics 20:367–378. doi:10.1148/radiographics.20.2.g00mc10367

    Article  PubMed  CAS  Google Scholar 

  26. Kilickesmez O, Inci E, Atilla S, et al. (2009) Diffusion-weighted imaging of the renal and adrenal lesions. J Comput Assist Tomogr 33:828–833. doi:10.1097/RCT.0b013e31819f1b83

    Article  PubMed  Google Scholar 

  27. Venkatesan AM, Wood BJ, Gervais DA (2011) Percutaneous ablation in the kidney. Radiology 261:375–391. doi:10.1148/radiol.11091207

    Article  PubMed  PubMed Central  Google Scholar 

  28. Miller FH, Wang Y, McCarthy RJ, et al. (2010) Utility of diffusion-weighted MRI in characterization of adrenal lesions. Am J Roentgenol 194:179–185. doi:10.2214/AJR.09.2891

    Article  Google Scholar 

  29. Boland GWL, Blake MA, Hahn PF, Mayo-Smith WW (2008) Incidental adrenal lesions: principles, techniques, and algorithms for imaging characterization. Radiology 249:756–775. doi:10.1148/radiol.2493070976

    Article  PubMed  Google Scholar 

  30. Haider MA, Ghai S, Jhaveri K, Lockwood G (2004) Chemical shift MR imaging of hyperattenuating (>10 HU) adrenal masses: does it still have a role? Radiology 231:711–716. doi:10.1148/radiol.2313030676

    Article  PubMed  Google Scholar 

  31. Ichikawa T, Erturk SM, Motosugi U, et al. (2007) High-b value diffusion-weighted MRI for detecting pancreatic adenocarcinoma: Preliminary results. Am J Roentgenol 188:409–414. doi:10.2214/AJR.05.1918

    Article  Google Scholar 

  32. Fukukura Y, Takumi K, Kamimura K, et al. (2012) Pancreatic adenocarcinoma: variability of diffusion-weighted MR imaging findings. Radiology 263:732–740. doi:10.1148/radiol.12111222

    Article  PubMed  Google Scholar 

  33. De Robertis R (2015) Diffusion-weighted imaging of pancreatic cancer. World J Radiol 7:319. doi:10.4329/wjr.v7.i10.319

    Article  Google Scholar 

  34. Thomas S, Kayhan A, Lakadamyali H, Oto A (2012) Diffusion MRI of acute pancreatitis and comparison with normal individuals using ADC values. Emerg Radiol 19:5–9. doi:10.1007/s10140-011-0983-2

    Article  PubMed  Google Scholar 

  35. Shinya S, Sasaki T, Nakagawa Y, et al. (2008) Acute pancreatitis successfully diagnosed by diffusion-weighted imaging: a case report. World J Gastroenterol 14:5478–5480. doi:10.3748/wjg.14.5478

    Article  PubMed  PubMed Central  Google Scholar 

  36. Tatar İG, Aydın H, Yılmaz KB, Hekimoğlu B (2015) Diagnosis of acute pancreatitis by diffusion-weighted. Magn Reson Imaging . doi:10.5152/UCD.2014.2475

    Article  Google Scholar 

  37. Wang Y, Miller FH, Chen ZE, et al. (2011) Diffusion-weighted MR imaging of solid and cystic lesions of the pancreas. RadioGraphics 31:E47–E64. doi:10.1148/rg.313105174

    Article  PubMed  Google Scholar 

  38. Dhanda S, Thakur M, Kerkar R, Jagmohan P (2014) Diffusion-weighted imaging of gynecologic tumors: diagnostic pearls and potential pitfalls. Radiographics 34:1393–1416. doi:10.1148/rg.345130131

    Article  PubMed  Google Scholar 

  39. Katayama M, Masui T, Kobayashi S, et al. (2002) Diffusion-weighted echo planar imaging of ovarian tumors: is it useful to measure apparent diffusion coefficients? J Comput Assist Tomogr 26:250–256

    Article  PubMed  Google Scholar 

  40. Koh D-M, Sohaib A (2012) Diffusion-weighted imaging of the male pelvis. Radiol Clin North Am 50:1127–1144. doi:10.1016/j.rcl.2012.08.008

    Article  PubMed  Google Scholar 

  41. Malayeri AA, El Khouli RH, Zaheer A, et al. (2011) Principles and applications of diffusion-weighted imaging in cancer detection, staging, and treatment follow-up. Radiographics 31:1773–1791. doi:10.1148/rg.316115515

    Article  PubMed  Google Scholar 

  42. Yoshimitsu K, Kiyoshima K, Irie H, et al. (2008) Usefulness of apparent diffusion coefficient map in diagnosing prostate carcinoma: correlation with stepwise histopathology. J Magn Reson Imaging 27:132–139. doi:10.1002/jmri.21181

    Article  PubMed  Google Scholar 

  43. Lim HK, Kim JK, Kim KA, Cho K (2009) Prostate cancer: apparent diffusion coefficient map with T2-weighted images for detection. Radiology 250:145–151

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Vlad Bura.

Ethics declarations

Funding

There is no funding associated with this manuscript.

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lall, C., Bura, V., Lee, T.K. et al. Diffusion-weighted imaging in hemorrhagic abdominal and pelvic lesions: restricted diffusion can mimic malignancy. Abdom Radiol 43, 1772–1784 (2018). https://doi.org/10.1007/s00261-017-1366-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00261-017-1366-2

Keywords

Navigation