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Celiac disease: a clinical review

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Abdominal Radiology Aims and scope Submit manuscript

Abstract

Celiac disease (CD) is an immune-mediated inflammatory enteropathy triggered by gluten exposure in genetically susceptible individuals. It has a high prevalence approaching 1% of the US population. A high index of suspicion is warranted to diagnose CD as frequently patients present with extraintestinal or atypical manifestations. CD is diagnosed by a combination of serum serologies and duodenal biopsies. The majority of patients will respond to a lifelong gluten-free diet which is the cornerstone of therapy. Complications such as refractory CD, ulcerative jejunoileitis, enteropathy associated T-cell lymphoma and small bowel adenocarcinoma occur in a minority of patients.

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Abbreviations

CD:

Celiac disease

GFD:

Gluten-free diet

EATL:

Enteropathy-associated T-cell lymphoma

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No funding was received for this study.

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The authors declare that they have no conflict of interest.

Disclosure

Joseph A. Murray (JAM): grant support from the National Institutes of Health (money paid to institution) and Alba Therapeutics (money paid to institution); Oberkotter Foundation (Oberkotter #1) (money paid to institution) and Broad Medical Research Program at CCFA (CCFA 342367) (money paid to institution); advisory boards Celimmune, LLC (money paid to JAM); AMAG Pharmaceuticals (money paid to JAM), Entera Health, Inc (money paid to JAM), Sonomaceuticals, LLC (money paid to JAM), BioLineRx (money paid to JAM), GlaxoSmithKline (GSK) (money paid to JAM), Genentech (money paid to JAM), Glenmark Pharmaceuticals Ltd (money paid to JAM); consultant to Boehringer Ingelheim (money paid to JAM); holds equity options in Torax (money paid to JAM and institution). Other authors declare that they have no disclosures.

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Authors and Affiliations

  1. Division of Gastroenterology & Hepatology, Mayo Clinic, 200 First Street, S.W., Rochester, MN, 55905, USA

    Badr Al-Bawardy, Alberto Rubio-Tapia, David H. Bruining, Stephanie L. Hansel & Joseph A. Murray

  2. Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA

    D. Chamil Codipilly

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  1. Badr Al-Bawardy
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  2. D. Chamil Codipilly
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  3. Alberto Rubio-Tapia
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  5. Stephanie L. Hansel
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  6. Joseph A. Murray
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Correspondence to Badr Al-Bawardy.

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Al-Bawardy, B., Codipilly, D.C., Rubio-Tapia, A. et al. Celiac disease: a clinical review. Abdom Radiol 42, 351–360 (2017). https://doi.org/10.1007/s00261-016-1034-y

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