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Influence of androgen deprivation therapy on choline PET/CT in recurrent prostate cancer

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

Recurrent prostate cancer is usually treated by combining radiotherapy and androgen deprivation therapy. To stage the cancer, choline positron emission tomography (PET)/CT can be performed. It is generally thought that androgen deprivation therapy does not influence choline PET/CT. In this article we focus on the molecular backgrounds of choline and androgens, and the results of preclinical and clinical studies performed using PET/CT.

Methods

Using PubMed, we looked for the relevant articles about androgen deprivation therapy and choline PET/CT.

Results

During ADT, a tendency of decreased uptake of choline in prostate cancer was observed, in particular in hormone-naïve patients.

Conclusion

We conclude that in order to prevent false-negative choline PET/CT scans androgen deprivation should be withheld prior to scanning, especially in hormone-naïve patients.

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Authors and Affiliations

  1. Department of Urology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands

    Rutger J. Dost, Anthonius J. Breeuwsma & Igle J. de Jong

  2. Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

    Andor W. J. M. Glaudemans

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  1. Rutger J. Dost
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Correspondence to Rutger J. Dost.

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Dost, R.J., Glaudemans, A.W.J.M., Breeuwsma, A.J. et al. Influence of androgen deprivation therapy on choline PET/CT in recurrent prostate cancer. Eur J Nucl Med Mol Imaging 40 (Suppl 1), 41–47 (2013). https://doi.org/10.1007/s00259-013-2398-7

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  • DOI: https://doi.org/10.1007/s00259-013-2398-7

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