Skip to main content

Advertisement

SpringerLink
Log in

Short-term spontaneous regression of myxofibrosarcoma in the scapular region

  • Case Report
  • Published:
Skeletal Radiology Aims and scope Submit manuscript

Abstract

Spontaneous regression of cancer is a well-known but rare phenomenon, and it is extremely rare for sarcomas. The current case is an 85-year-old woman with a multinodular lesion diagnosed as myxofibrosarcoma in the scapular region. The maximum size of the tumor at the initial visit was 10 cm, and it decreased to less than 2 cm without any treatment. After a period of regression of about 6 months, the tumor began to grow, and resection was performed. No prior case of spontaneous regression has been reported in myxofibrosarcoma or other primary sarcomas. Interestingly, the regression took place after the occurrence of pneumonia, suggesting a possible relationship.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

References

  1. Kim SW, Wylie J. Spontaneous regression of pulmonary metastases from breast angiosarcoma. Sarcoma. 2008;2008(940656).

  2. Jemal ASR, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60(5):277–300.

    Article  PubMed  Google Scholar 

  3. Herreros-Villanueva M, Hijona E, Cosme A, Bujanda L. Spontaneous regression of pancreatic cancer: real or a misdiagnosis? World J Gastroenterol. 2012;18(23):2902–8.

    Article  PubMed Central  PubMed  Google Scholar 

  4. Abdelrazeq AS. Spontaneous regression of colorectal cancer: a review of cases from 1900 to 2005. Int J Color Dis. 2007;22(7):727–36.

    Article  Google Scholar 

  5. Buinauskas P, Brown ER, Cole WH. Antigenic behavior of Walker 256 tumor in Sprague–Dawley rats. Surgery. 1966;60(4):902–7.

    CAS  PubMed  Google Scholar 

  6. Everson TC, Cole WH. Spontaneous regression of cancer. Philadelphia: WB Saunders; 1966.

    Google Scholar 

  7. Challis GB, Stam HJ. The spontaneous regression of cancer. A review of cases from 1900 to 1987. Acta Oncol. 1990;29(5):545–50.

    Article  CAS  PubMed  Google Scholar 

  8. Sabaté JM, Llauger J, Torrubia S, Amores S, Franquet T. Osteosarcoma of the abdominal wall with spontaneous regression of lung metastases. AJR Am J Roentgenol. 1998;171(3):691–2.

    Article  PubMed  Google Scholar 

  9. Ota S, Shinagawa K, Ueoka H, Tada S, Tabata M, Hamazaki S, et al. Spontaneous regression of metastatic endometrial stromal sarcoma. Jpn J Clin Oncol. 2002;32(2):71–4.

    Article  PubMed  Google Scholar 

  10. Enzinger FM, Weiss SW. Soft tissue tumors. St. Louis: CV Mosby; 2008.

    Google Scholar 

  11. Willems SM, Debiec-Rychter M, Szuhai K, Hogendoorn PC, Sciot R. Local recurrence of myxofibrosarcoma is associated with increase in tumour grade and cytogenetic aberrations, suggesting a multistep tumour progression model. Mod Pathol. 2006;19(3):407–16.

    Article  PubMed  Google Scholar 

  12. Nam SW, Han JY, Kim JI, Park SH, Cho SH, Han NI, et al. Spontaneous regression of a large hepatocellular carcinoma with skull metastasis. J Gastroenterol Hepatol. 2005;20(3):488–92.

    Article  PubMed  Google Scholar 

  13. Papac RJ. Spontaneous regression of cancer: possible mechanisms. In Vivo. 1998;12(6):571–8.

    CAS  PubMed  Google Scholar 

  14. Broder S, Karp JE. Progress against cancer. J Cancer Res Clin Oncol. 1995;121(11):633–47.

    CAS  PubMed  Google Scholar 

  15. Ozden I, Dizdaroğlu F, Poyanli A, Emre A. Spontaneous regression of a pancreatic head mass and biliary obstruction due to autoimmune pancreatitis. Pancreatology. 2005;5(2–3):300–3.

    Article  PubMed  Google Scholar 

  16. Wooff JC, Trites JR, Walsh NM, Bullock MJ. Complete spontaneous regression of metastatic Merkel cell carcinoma: a case report and review of the literature. Am J Dermatopathol. 2010;32(6):614–7.

    Article  CAS  PubMed  Google Scholar 

  17. Kalialis LV, Drzewiecki KT, Hm K. Spontaneous regression of metastases from melanoma: review of the literature. Melanoma Res. 2009;19(5):275–82.

    Article  PubMed  Google Scholar 

  18. Bir AS, Fora AA, Levea C, Fakih MG. Spontaneous regression of colorectal cancer metastatic to retroperitoneal lymph nodes. Anticancer Res. 2009;29(2):465–8.

    PubMed  Google Scholar 

  19. Lam KC, Ho JC, Yeung RT. Spontaneous regression of hepatocellular carcinoma: a case study. Cancer. 1982;15(50):2.

    Google Scholar 

  20. Kappauf H, Gallmeier WM, Wünsch PH, Mittelmeier HO, Birkmann J, Büschel G, et al. Complete spontaneous remission in a patient with metastatic non-small-cell lung cancer. Case report, review of the literature, and discussion of possible biological pathways involved. Ann Oncol. 1997;8(10):1031–9.

    Article  CAS  PubMed  Google Scholar 

  21. Coley WB. Contribution to the knowledge of sarcoma. Ann Surg. 1891;14:199–220.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  22. Hoption Cann SA, van Netten JP, van Netten C, Glover DW. Spontaneous regression: a hidden treasure buried in time. Med Hypotheses. 2002;58(2):115–9.

    Article  CAS  PubMed  Google Scholar 

Download references

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

AS administered the treatment and drafted the manuscript. ES and MH made the diagnosis as pathologists.

Author information

Authors and Affiliations

  1. Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Akio Sakamoto

  2. Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan

    Eisuke Shiba & Masanori Hisaoka

Authors
  1. Akio Sakamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eisuke Shiba
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Masanori Hisaoka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Akio Sakamoto.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sakamoto, A., Shiba, E. & Hisaoka, M. Short-term spontaneous regression of myxofibrosarcoma in the scapular region. Skeletal Radiol 43, 1487–1490 (2014). https://doi.org/10.1007/s00256-014-1914-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00256-014-1914-6

Keywords

Search

Navigation