Abstract.
Objective. To investigate the effect of fluconazole on the kinetics of mexiletine.
Methods.
Six healthy male volunteers participated in a crossover study. On the 1st day, the subjects received 200 mg mexiletine alone. On days 2–7 they received 200 mg fluconazole orally, and on day 8 they received 200 mg mexiletine and 200 mg fluconazole concomitantly. In a third phase two subjects received 400 mg fluconazole daily.
Results.
No differences in concentrations were observed between the three phases. The area under the concentration curves (AUC) after administration of mexiletine alone and in combination with fluconazole 200 mg/day were 6.63 and 7.31 μg ⋅ h ⋅ ml−1, respectively.
Conclusion.
These findings suggest that fluconazole does not inhibit mexiletine metabolism.
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Received: 7 July 1995/Accepted in revised form: 19 September 1995
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Ueno, K., Yamaguchi, R., Tanaka, K. et al. Lack of a kinetic interaction between fluconazole and mexiletine. E J Clin Pharmacol 50, 129–131 (1996). https://doi.org/10.1007/s002280050080
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DOI: https://doi.org/10.1007/s002280050080