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Characterization of surgical aerosols by the compact single-particle mass spectrometer LAMPAS 3

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Abstract

A new method is presented using an optical particle counter and the compact mobile laser mass spectrometer LAMPAS 3 for in situ analysis of single particles generated by electrosurgical dissection of biological tissues. The instrumental performance is demonstrated for analysing aerosol particles formed during rapid thermal evaporation of porcine liver and porcine kidney tissues. Particle number concentrations of up to 5,000 particles per cubic centimetre were detected during surgical dissection. Chemical analysis of tissue particles was performed by bipolar time-of-flight mass spectrometry. The application of an online mass spectrometric particle analysis for surgical aerosols is reported here for the first time.

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Acknowledgement

This work was supported by the Deutsche Forschungsgemeinschaft (DFG), grant no. HI 857/4-1, and by the research programme “Landes-Offensive zur Entwicklung Wissenschaftlich-oekonomischer Exzellenz—LOEWE”, research focus “AmbiProbe”, State of Hesse, Germany.

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Authors and Affiliations

  1. Institute of Inorganic and Analytical Chemistry, Justus Liebig University Giessen, 35392, Giessen, Germany

    K.-P. Hinz, E. Gelhausen, K.-C. Schäfer, Z. Takats & B. Spengler

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  1. K.-P. Hinz
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  2. E. Gelhausen
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  3. K.-C. Schäfer
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  4. Z. Takats
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  5. B. Spengler
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Corresponding author

Correspondence to B. Spengler.

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Published in the special issue Aerosol Analysis with guest editor Ralf Zimmermann.

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Hinz, KP., Gelhausen, E., Schäfer, KC. et al. Characterization of surgical aerosols by the compact single-particle mass spectrometer LAMPAS 3. Anal Bioanal Chem 401, 3165–3172 (2011). https://doi.org/10.1007/s00216-011-5465-6

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  • DOI: https://doi.org/10.1007/s00216-011-5465-6

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