Skip to main content
SpringerLink
Log in

Investigation of the role of hyperbaric oxygen therapy in cisplatin-induced nephrotoxicity in rats

  • Organ Toxicity and Mechanisms
  • Published:
Archives of Toxicology Aims and scope Submit manuscript

Abstract

Cisplatin (CP) is an effective chemotherapeutic agent used in the treatment of a variety of solid tumours. The most frequently observed side-effect of the use of CP is nephrotoxicity. Recently, evidence has been demonstrated that reactive oxygen species forming in the tubular epithelium play an important role in CP-linked nephrotoxicity. The aim of the study was to observe the effect of hyperbaric oxygen (HBO) therapy on CP nephrotoxicity, a subject which has not been studied previously. Wistar rats were treated with CP (a single intraperitoneal (IP) dose of 0.6 mg/100 g) alone and in combination with HBO (60 min every day for seven days at 2.5×atmospheric pressure). Effects of the treatment on renal function and histology were determined. In analyses at the end of the study it was observed that serum urea, creatinine, and daily urinary protein excretion levels of the CP group were higher than at the start of the study, and that the creatinine clearance level had fallen (P<0.05). There was no significant difference between the CP+HBO group and HBO group serum urea, creatinine, creatinine clearance, and daily urinary protein excretion levels at the beginning and end of the study (P>0.05). Histopathological examination showed that the necrosis score in the proximal tubule epithelial cells and average apoptitic cell numbers in the CP group were higher than those in the CP+HBO and HBO groups (P<0.05). There was no statistical difference between the CP+HBO group and the HBO group in terms of necrosis score in the proximal tubule epithelial cells and the percentage of distal tubules containing hyaline casts in the lumen. In conclusion, in this study it was observed that in experimental study of CP nephrotoxicity the synchronous application of HBO therapy with CP prevents kidney damage.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1 A

Similar content being viewed by others

References

  • Appenroth D, Fröb S, Kertsen L, Splinter K, Winnefeld K (1997) Protective effects of vitamin E and C on cisplatin nephrotoxicity in developing rats. Arch Toxicol 71:677–683

    Article  CAS  PubMed  Google Scholar 

  • Baliga R, Ueda N, Walker PD, Shah SV (1999) Oxidant mechanisms in toxic acute renal failure. Drug Metab Rev 31:971–997

    Article  CAS  PubMed  Google Scholar 

  • Burkhart KK, Hall AH, Gerace R, Rumack BH (1991) Hyperbaric oxygen treatment for carbon tetrachloride poisoning. Drug Safety 6:332–338

    CAS  PubMed  Google Scholar 

  • Cameron JS, Greger R (1998) Renal function and testing of function. In: Davison AM, Cameron JS, Grünfeld JP, Kerr DNS, Ritz E, Winearls CG (eds) Oxford textbook of clinical nephrology, vol 1, China. Oxford Medical Publications, pp 39–69

  • Davis C, Nick H, Agarwal A (2001) Manganese superoxide dismutase attenuates cisplatin-induced renal injury: importance of superoxide. J Am Soc Nephrol 12:2683–2690

    CAS  PubMed  Google Scholar 

  • Hink J, Jansen E (2001) Are superoxide and/or hydrogen peroxide responsible for some of the beneficial effects of hyperbaric oxygen therapy? Med Hypotheses 57:764–769

    Article  CAS  PubMed  Google Scholar 

  • Huang Y, Zhou S, Qui L, Wu J, Xu C (1997) Effects of zinc gluconate on nephrotoxicity and glutathione metabolism disorder induced by cisplatin in mice. Drug Metab Drug Interact 14:41–46

    Google Scholar 

  • Jamieson D (1989) Oxygen toxicity and reactive oxygen metabolites in mammals. Free Radic Biol Med 7:87–108

    Article  CAS  PubMed  Google Scholar 

  • Kruidering M, van de Water B, de Heer E, Mulder GJ, Nagelkerke JF (1997) Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain. J Pharmacol Exp Ther 280:638–649

    CAS  PubMed  Google Scholar 

  • Kuhlmann MK, Burkhardt G, Köhler H (1997) Insights into potential cellular mechanisms of cisplatin nephrotoxicity and their clinical application. Nephrol Dial Transplant 12:2478–2480

    Article  CAS  PubMed  Google Scholar 

  • Lebwohl D, Canetta R (1998) Clinical development of platinum complexes in cancer therapy: an historical perspective and an update. Eur J Cancer 34:1522–1534

    Article  CAS  PubMed  Google Scholar 

  • Nath KA, Norby SM (2000) Reactive oxygen species and acute renal failure. Am J Med 109:665–678

    Article  CAS  PubMed  Google Scholar 

  • Nikkanen HE, Burns MM (2004) Severe hydrogen sulfide exposure in a working adolescent. Pediatrics 113:927–929

    Article  PubMed  Google Scholar 

  • Özen S, Akyol Ö, Iraz M, Söğüt S, Özuğurlu F, Özyurt H, Odacı E, Yıldırım Z (2004) Role of caffeic acid phenethyl ester, an active component of propolis, against cisplatin-induced nephrotoxicity in rats. J Appl Toxicol 24:27–35

    Google Scholar 

  • Ramesh G, Reeves B (2004) Salicylate reduces cisplatin nephrotoxicity by inhibition of tumor necrosis factor-α. Kidney Int 65:490–498

    Article  CAS  PubMed  Google Scholar 

  • Reiffenstein RJ, Hulbert WC, Roth SH (1992) Toxicology of hydrogen sulfide. Annu Rev Pharmacol Toxicol 32:109–134

    Article  CAS  PubMed  Google Scholar 

  • Sadzuka Y, Shoji T, Takino Y (1992) Effect of cisplatin on the activities of enzymes which protect against lipid peroxidation. Biochem Pharmacol 43:1873–1875

    Article  Google Scholar 

  • Sahni T, Singh P, John MJ (2003) Hyperbaric oxygen therapy: current trends and applications. J Assoc Physicians India 51:280–284

    CAS  PubMed  Google Scholar 

  • Strauss MB, Bryant B (2002) Hyperbaric oxygen. Orthopedics 25:303–310

    PubMed  Google Scholar 

  • Thom SR, Elbuken ME (1991) Oxygen-dependent antagonism of lipid peroxidation. Free Radic Biol Med 10:413–426

    Article  CAS  PubMed  Google Scholar 

  • Thom SR (1993) Functional inhibition of leukocyte B2 integrins by hyperbaric oxygen in carbon monoxide-mediated brain injury in rats. Toxicol Appl Pharmacol 123:248–256

    Article  CAS  PubMed  Google Scholar 

  • Tibbles PM, Edelsberg JS (1996) Hyperbaric-oxygen therapy. N Engl J Med 334:1642–1648

    Article  CAS  PubMed  Google Scholar 

  • Tomaszewski CA, Thom SR (1994) Use of hyperbaric oxygen in toxicology. Emerg Med Clin North Am 12:437–459

    CAS  PubMed  Google Scholar 

  • Ulubaş B, Çımen MYB, Apa DD, Saritaş E, Muşlu N, Çımen ÖB (2003) The protective effects of acetyl salicylic acid on free radical production in cisplatin induced nephrotoxicity: an experimental rat model. Drug Chem Toxicol 26:259–270

    Article  PubMed  Google Scholar 

  • Weber LW, Boll M, Stampfl A (2003) Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol 33:105–136

    CAS  PubMed  Google Scholar 

  • Zhang JG, Lindup WE (1993) Role of mitochondria in cisplatin-induced oxidative damage exhibited by rat renal cortical slices. Biochem Pharmacol 45:2215–2222

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nephrology, Gülhane Military Medical Academy, Haydarpaşa Training Hospital, Kadıköy/İstanbul, Turkey

    Enes Murat Atasoyu & Rıfkı Evrenkaya

  2. Department of Underwater and Hyperbaric Medicine, Gülhane Military Medical Academy, Haydarpaşa Training Hospital, 81010, Kadıköy/İstanbul, Turkey

    Senol Yildiz

  3. Department of Oncology, Gülhane Military Medical Academy, Haydarpaşa Training Hospital, 81010, Kadıköy/İstanbul, Turkey

    Oguz Bilgi & E Gökhan Kandemir

  4. Department of Pathology, Gülhane Military Medical Academy, Haydarpaşa Training Hospital, 81010, Kadıköy/İstanbul, Turkey

    Hakan Cermik

  5. Department of Underwater and Hyperbaric Medicine, Istanbul University Medical Faculty, 34390, Çapa/İstanbul, Turkey

    Samil Aktas

  6. Department of Biochemistry, Gülhane Military Medical Academy, Haydarpaşa Training Hospital, 81010, Kadıköy/İstanbul, Turkey

    Mustafa Gültepe

Authors
  1. Enes Murat Atasoyu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Senol Yildiz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Oguz Bilgi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hakan Cermik
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Rıfkı Evrenkaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Samil Aktas
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Mustafa Gültepe
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. E Gökhan Kandemir
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Senol Yildiz.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Atasoyu, E.M., Yildiz, S., Bilgi, O. et al. Investigation of the role of hyperbaric oxygen therapy in cisplatin-induced nephrotoxicity in rats. Arch Toxicol 79, 289–293 (2005). https://doi.org/10.1007/s00204-004-0627-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00204-004-0627-3

Keywords

Search

Navigation