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Tracking of bone mass from childhood to puberty: a 7-year follow-up. The CHAMPS study DK

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Abstract

Summary

Bone mass in childhood is highly influenced by puberty. At the same age, bone mass was higher for pubertal than pre-pubertal children. A high level of tracking during 7 years from childhood through puberty was shown, indicating that early levels of bone mass may be important for later bone health.

Introduction

Bone mass development in childhood varies by sex and age, but also by pubertal stage. The objectives of this study were to (1) describe bone mass development in childhood as it relates to pubertal onset and to (2) determine the degree of tracking from childhood to adolescence.

Methods

A longitudinal study with 7 years of follow-up was initiated in 2008 to include 831 children (407 boys) aged 8 to 17 years. Participants underwent whole body dual-energy X-ray absorptiometry (DXA) scanning, blood collection to quantify luteinizing hormone levels, and Tanner stage self-assessment three times during the 7-year follow-up. Total body less head bone mineral content, areal bone mineral density, and bone area were used to describe development in bone accrual and to examine tracking over 7 years.

Results

Bone mass in pubertal children is higher than that of pre-pubertal children at the same age. Analysing tracking with quintiles of bone mass Z-scores in 2008 and 2015 showed that more than 80% of participants remained in the same or neighbouring quintile over the study period. Tracking was confirmed by correlation coefficients between Z-scores at baseline and 7-year follow-up (range, 0.80–0.84).

Conclusions

Bone mass is highly influenced by pubertal onset, and pubertal stage should be considered when examining children’s bone health. Because bone mass indices track from childhood into puberty, children with low bone mass may be at risk of developing osteoporosis later in life.

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Acknowledgements

We thank participants and schools for their participation in the Childhood Health Activity and Motor Performance School study.

Funding

The study was supported by The Danish foundation “Tryg-fonden”, the Region of Southern Denmark, Hospital of Southern Jutland, and “Kirsten og Freddy Johansens Fond”.

Author information

Authors and Affiliations

  1. Hans Christian Andersen Children’s Hospital, Odense University Hospital, Kløvervænget 23C, 5000, Odense C, Denmark

    M. S. Rønne, M. Heidemann, A. Schou, S. Husby & C. Mølgaard

  2. Department of Clinical Research, University of Southern Denmark, Winsløwparken 19, 3, 5000, Odense C, Denmark

    M. S. Rønne & S. Husby

  3. Emergency Department, Hospital of South Jutland, Kresten Philipsens Vej 15, 6200, Aabenraa, Denmark

    J. O. Laursen

  4. Hospital of South Jutland, Kresten Philipsens Vej 15, 6200, Aabenraa, Denmark

    A. B. Bojesen

  5. Department of Clinical Biochemistry, Rigshospitalet, Glostrup, Valdemar Hansens Vej 1-23, 2600, Glostrup, Denmark

    L. Lylloff

  6. Department of Clinical Biochemistry, Hospital Unit West, Gl. Landevej 61, 7400, Herning, Denmark

    L. Lylloff

  7. Research in Childhood Health, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark

    N. Wedderkopp

  8. Department of Nutrition, Exercise and Sports, University of Copenhagen, Nørre Allé 51, 2200, Copenhagen N, Denmark

    C. Mølgaard

Authors
  1. M. S. Rønne
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  2. M. Heidemann
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  6. L. Lylloff
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  7. S. Husby
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  8. N. Wedderkopp
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  9. C. Mølgaard
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Corresponding author

Correspondence to M. S. Rønne.

Ethics declarations

Ethical approval

Children and parents have received information both at school meetings and additional written information about the study. The parents signed informed consent forms before examination. Participation was at any time voluntary. Permission to conduct the CHAMPS-study DK was granted by the Regional Scientific Ethical Committee of Southern Denmark (Project ID: S2008-0047, S-20140105) and were in accordance with the ethical standards of the 1964 Helsinki declaration and its later amendments.

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Rønne, M.S., Heidemann, M., Schou, A. et al. Tracking of bone mass from childhood to puberty: a 7-year follow-up. The CHAMPS study DK. Osteoporos Int 29, 1843–1852 (2018). https://doi.org/10.1007/s00198-018-4556-z

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