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Vertebroplasty increases trabecular microfractures in elderly female cadaver spines

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Abstract

Summary

This study assessed whether vertebroplasty increases trabecular bone microfractures in adjacent vertebrae of elderly female cadavers. Results indicated microfractures were almost two times greater in superior adjacent vertebrae for vertebroplasty treated spines compared to non-treated controls. This finding may aid in developing improved treatments for osteoporotic women with vertebral fractures.

Introduction

Although vertebroplasty may stabilize compression fractures and reduce pain, subsequent vertebral fractures occur in approximately 25 % of patients, reducing the overall safety of this procedure. This is particularly a concern in vertebrae surrounding the treated level where bone cement may cause abnormal transfer of forces to adjacent spinal structures. Therefore, the objective of this study was to quantify the effects of vertebroplasty on local trabecular bone damage in adjacent vertebrae.

Methods

Five level motion segments (T11-L3) from osteopenic/osteoporotic female cadaver spines (T-score −2.9 ± 1.0) were assigned into either vertebroplasty or control (no vertebroplasty) groups (n = 10/group) such that T-score, trabecular microarchitecture, and age were similar between groups. Compression fractures were created in the L 1 vertebra of all specimens and PMMA bone cement was injected into the fractured vertebra of vertebroplasty specimens. All spine segments were subjected to cyclic axial compression (685–1370 N) for 115,000 cycles. Post-testing, trabecular cubes were cut from adjacent (T12 and L2) vertebral bodies and histologically processed. Trabecular microfractures were identified and normalized by bone area in each section.

Results

There were significantly more trabecular microfractures (p < 0.001) in superior adjacent vertebral bodies of the vertebroplasty group (0.091 ± 0.025 microfractures/mm2) when compared to the control group (0.049 ± 0.018 microfractures/mm2). However, there was no difference in trabecular microfractures (p = 0.835) between vertebroplasty (0.045 ± 0.022 microfractures/mm2) and control groups (0.035 ± 0.013 microfractures/mm2) for inferior adjacent vertebral bodies.

Conclusions

Vertebroplasty specifically impacts the superior adjacent vertebrae of elderly female spines resulting in almost two times more trabecular microfractures when compared to non-treated controls.

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Acknowledgments

This research study was funded by a grant through the FDA’s Office of Women’s Health. The authors would like to thank Ronald Wade and Anthony Pleasant for cadaver procurement, and Steven Kaplan and Sarah Schmiedel for histology of trabecular cores.

Conflicts of interest

None.

Author information

Authors and Affiliations

  1. Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Applied Mechanics, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Building 62, Room 2210, Silver Spring, MD, 20993-0002, USA

    S. Nagaraja, H. K. Awada & M. L. Dreher

Authors
  1. S. Nagaraja
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  2. H. K. Awada
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  3. M. L. Dreher
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Corresponding author

Correspondence to S. Nagaraja.

Additional information

Srinidhi Nagaraja hold a PhD. U.S. Food and Drug Administration

Hassan K. Awada hold a BS. U.S. Food and Drug Administration

Maureen L. Dreher hold a PhD. U.S. Food and Drug Administration

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Nagaraja, S., Awada, H.K. & Dreher, M.L. Vertebroplasty increases trabecular microfractures in elderly female cadaver spines. Osteoporos Int 26, 2029–2034 (2015). https://doi.org/10.1007/s00198-015-3105-2

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  • DOI: https://doi.org/10.1007/s00198-015-3105-2

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