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Hypertrophic cervical elongation: clinical and histological correlations

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Abstract

Introduction and hypothesis

The objective of this study is to define the diagnosis of hypertrophic cervical elongation clinically and to perform histochemical and histological evaluations of patients with and without hypertrophic cervical elongation.

Methods

This prospective study was conducted at Louisiana State University between December 2005 and May 2008. Fourteen women with cervical elongation and 28 women without prolapse were studied.

Results

The amounts of elastin, collagen, and smooth muscle did not differ between study and control groups. Estrogen and progesterone receptor content in cervical elongation were elevated compared to the cervix of women without prolapse. Hypertrophic cervical elongation was defined as the difference between point C and point D of the Pelvic Organ Prolapse Quantification system greater than 8 cm.

Conclusions

Estrogen and progesterone receptor levels are greater in women with hypertrophic cervical elongation compared with a normal cervix.

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Fig. 1

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Abbreviations

POP:

Pelvic organ prolapse

POPQ:

Pelvic Organ Prolapse Quantification

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Acknowledgments

This study was funded by the Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, New Orleans, Louisiana.

Conflicts of interest

None.

Author information

Authors and Affiliations

  1. Johns Hopkins University, Baltimore, MD, USA

    Okechukwu A. Ibeanu, Ralph R. Chesson, Dane Sandquist, Javier Perez, Kerri Santiago & Thomas E. Nolan

  2. 600 North Wolfe Street, Phipps 281, Baltimore, MD, 21202, USA

    Okechukwu A. Ibeanu

Authors
  1. Okechukwu A. Ibeanu
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  2. Ralph R. Chesson
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  3. Dane Sandquist
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  4. Javier Perez
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  5. Kerri Santiago
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  6. Thomas E. Nolan
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Corresponding author

Correspondence to Okechukwu A. Ibeanu.

Appendix

Appendix

Cervical elongation study data sheet key

  • Race:

    • White: 1

    • Black: 2

    • Hispanic: 3

    • Asian: 4

  • Parity:

    • 0: nulliparity

    • 1: 1–4

    • 2: 5–9

    • 3: 10 or more

  • Category:

    • No cervical prolapse: 0

    • Cervical prolapse: 1

  • Vaginal capacity:

    • Reduced: 0

    • Adequate: 1

    • Normal: 2

  • Prior hormone therapy:

    • No: 0

    • Yes: 1

  • Current hormone therapy:

    • No: 0

    • Yes 2 years or more: 1

  • Prior abdominal surgery:

    • No: 0

    • Yes: 1

  • Prior pelvic surgery:

    • No: 0

    • Yes: 1

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Ibeanu, O.A., Chesson, R.R., Sandquist, D. et al. Hypertrophic cervical elongation: clinical and histological correlations. Int Urogynecol J 21, 995–1000 (2010). https://doi.org/10.1007/s00192-010-1131-3

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  • DOI: https://doi.org/10.1007/s00192-010-1131-3

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