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Tierexperimentelle Osteitismodelle

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Zusammenfassung

Trotz neuer laborchemischer, radiologischer bzw. nuklearmedizinischer Untersuchungsverfahren und neuer Operationstechniken stellt die Diagnose und Therapie der akuten und insbesondere der chronischen Osteitis auch in der heutigen Zeit ein großes Problem dar. Klinisch orientierte Osteitisforschung ist problematisch, da viele verschiedene Variablen in der Infektionsentstehung und zahlreiche verschiedene therapeutische Optionen bestehen. Die zur gezielten Untersuchung spezifischer Fragestellungen bezüglich Osteitispathogenese und Osteitistherapie notwendige Standardisierung ist in klinischen Patientenkollektiven nicht oder nur unzureichend gegeben. Folglich wurden schon früh tierexperimentelle Modelle etabliert, um unter standardisierten, reproduzierbaren Versuchbedingungen Erkenntnisse über die Osteitispathogenese und die Osteitistherapie zu gewinnen. Im vorliegenden Artikel wird ein Überblick über die bisher in der Osteitisforschung etablierten tierexperimentellen Modelle und den daraus gewonnenen Erkenntnissen gegeben.

Abstract

Despite new approaches in biochemical testing, radiologic and nuclear medicine and advances in surgical techniques, the problem of diagnosis and therapy of acute and chronic osteitis has not been finally solved. Clinical research on osteitis is problematic as there are many variables influencing the inflammatory process and a wide spectrum in therapeutic options exists, hampering research under defined conditions. Consequently, there was an early need for animal models. In vivo experimental settings were established to gain reproducible and reliable results under standardized conditions on the pathogenesis and therapy of osteitis. In this article, an overview of the hitherto established experimental animal models and the results of osteitis research on these models is given.

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Authors and Affiliations

  1. BG-Kliniken Bergmannsheil—Chirurgische Klinik und Poliklinik—Universitätsklinik Bochum

    T. Kälicke, C. Wingenfeld, G. Muhr & S. Arens

  2. AO-Research Institute Davos, Schweiz

    U. Schlegel

  3. Orthopädische Universitätsklinik Bonn

    C. Kraft

  4. Berufsgenossenschaftliche Kliniken Bergmannsheil—Chirurgische Klinik und Poliklinik—Universitätsklinik, Bürkle-de-la-Camp-Platz 1, 44789 , Bochum

    T. Kälicke

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  1. T. Kälicke
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  2. U. Schlegel
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  3. C. Kraft
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  5. G. Muhr
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Correspondence to T. Kälicke.

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Kälicke, T., Schlegel, U., Kraft, C. et al. Tierexperimentelle Osteitismodelle. Orthopäde 33, 260–266 (2004). https://doi.org/10.1007/s00132-003-0608-x

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