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NPR-C: a component of the natriuretic peptide family with implications in human diseases

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Abstract

The natriuretic peptide (NP) family includes atrial natriuretic peptide (ANP), B-type natriuretic peptide, C-type natriuretic peptide and their receptors NPR-A, NPR-B and NPR-C. The effects exerted by this hormonal system in the control of cardiovascular, renal and endocrine functions have been extensively investigated. Moreover, the involvement of NP in the pathogenesis of cardiovascular diseases has been demonstrated. Among the NP components, NPR-C has been described, at the time of its discovery, as the clearance receptor of NP devoid of any physiological functions. Emerging roles of NPR-C, however, have been highlighted over the last few years in relation to its effects on the cardiovascular system and other organs. These effects appear to be directly mediated through distinct cAMP-dependent intracellular mechanisms. Moreover, evidence has been accumulated on a potential pathophysiological role of NPR-C in human diseases. Ongoing studies from our group are revealing its involvement in the mediation of antiproliferative effects exerted on vascular cells by a molecular variant of human ANP. Thus, a new appraisal of NPR-C is overcoming the traditional view of a mere clearance receptor. This review focuses on the most important evidence supporting an involvement of NPR-C in mediating some of the actions of NP and its direct implication in cardiovascular diseases. The current state of knowledge highlights the need of further studies to better clarify the specific roles of NPR-C in pathophysiological processes.

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Acknowledgements

The present work was supported by a grant from the Italian Ministry of Health to MV and SR; by the Ingenious HyperCare European project to MV. We thank Dr. Giuliano Tocci for the critical revision of the manuscript.

Conflicts of interest

There are no conflicts of interest to disclose.

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Authors and Affiliations

  1. Chair and Division of Cardiology, 2nd School of Medicine, University Sapienza, Sant’Andrea Hospital, Via di Grottarossa 1035-9, Rome, Italy

    Speranza Rubattu, Sebastiano Sciarretta, Angelica Morriello, Camilla Calvieri, Allegra Battistoni & Massimo Volpe

  2. IRCCS Neuromed, Polo Molisano University Sapienza of Rome, Pozzilli (Isernia), Italy

    Speranza Rubattu & Massimo Volpe

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  1. Speranza Rubattu
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  4. Camilla Calvieri
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  5. Allegra Battistoni
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  6. Massimo Volpe
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Correspondence to Massimo Volpe.

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Rubattu, S., Sciarretta, S., Morriello, A. et al. NPR-C: a component of the natriuretic peptide family with implications in human diseases. J Mol Med 88, 889–897 (2010). https://doi.org/10.1007/s00109-010-0641-2

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  • DOI: https://doi.org/10.1007/s00109-010-0641-2

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