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Triglyceride-to-HDL cholesterol ratio

Predictive value for CHD severity and new-onset heart failure

Triglyzerid-HDL-Cholesterin-Ratio

Prädiktiver Wert für KHK-Schweregrad und neu auftretende Herzinsuffizienz

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Abstract

Objective

This study aimed to explore the association between the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio and the severity of coronary heart disease (CHD). It also evaluated the clinical role of the TG/HDL-C ratio in predicting in-hospital CHD events and the long-term prognosis of CHD patients.

Methods

According to the results of coronary angiography examinations, 317 patients were enrolled in the study and classified into a CHD group (n=233) and a control group (n=84). The TG/HDL-C ratio was calculated at baseline. The CHD group was then further classified into cases of single-branch stenosis (n=79), double-branch stenosis (n=73), and multi-branch stenosis (n=81). The Gensini score was calculated for each group to analyze the relationship between the TG/HDL-C ratio and the severity of CHD.

Results

The TG/HDL-C ratio in the CHD group was significantly higher than in the normal group (P < 0.001). The TG/HDL-C ratio was positively correlated with the Gensini score. The ratio was significantly higher in patients with new-onset heart failure than in those without heart failure events (P < 0.05). An average 3-year follow-up showed that the serum TG/HDL-C ratios of patients with adverse events were significantly higher than other patients (P <  0.01).

Conclusion

The TG/HDL-C ratio is predictive of the severity of CHD. It could also help predict in-hospital new-onset heart failure incidents of CHD patients.

Zusammenfassung

Ziel

Ziel war es, den Zusammenhang zwischen dem Verhältnis von Triglyzerid zu HDL-Cholesterin (TG-HDL-C-Ratio) und dem Schweregrad der koronaren Herzkrankheit (KHK) zu untersuchen sowie die klinische Bedeutung der TG-HDL-C-Ratio für die Prognose bei KHK während des stationären Aufenthalts und auf lange Sicht zu ermitteln.

Methoden

Entsprechend den Koronarangiographiebefunden wurden die 317 in die Studie aufgenommenen Patienten entweder in die KHK-Gruppe (n=233) oder die Kontrollgruppe (n=84) eingeteilt. Zu Studienbeginn wurde die TG-HDL-C-Ratio berechnet. Die KHK-Gruppe wurde dann unterteilt in Ein-Gefäß-Stenose (n=79), Zwei-Gefäß-Stenose (n=73) und Mehr-Gefäß-Stenose (n=81). Zur Auswertung der Beziehung zwischen der TG-HDL-C-Ratio und dem Schweregrad der KHK wurde der Gensini-Score für jede Gruppe berechnet.

Ergebnisse

Die TG-HDL-C-Ratio war in der KHK-Gruppe signifikant höher als in der Kontrollgruppe (p < 0,001). Dabei war die TG-HDL-C-Ratio positiv mit dem Gensini-Score korreliert. Bei Patienten mit neu aufgetretender Herzinsuffizienz war die TG-HDL-C-Ratio signifikant höher als bei Personen ohne Herzinsuffizienzereignisse (p < 0,05). In der durchschnittlichen Nachbeobachtungsphase von 3 Jahren zeigte sich, dass die Serum-TG-HDL-C-Ratio bei Patienten mit unerwünschten Ereignissen signifikant höher war als bei anderen Patienten (p <  0,01).

Schlussfolgerungen

Die TG-HDL-C-Ratio ist ein Prädiktor für den Schweregrad der KHK. Sie konnte auch zur Vorhersage neu auftretender Herzinsuffizienzereignisse während des stationären Aufenthalts bei KHK-Patienten beitragen.

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References

  1. Barzi F, Patel A, Woodward M et al (2005) A comparison of lipid variables as predictors of cardiovascular disease in the Asia Pacific region. Ann Epidemiol 15(5):405–413

    Article  CAS  PubMed  Google Scholar 

  2. Talmud P, Hawe E, Miller G, Humphries S (2002) Non-fasting apolipoprotein B and triglyceride levels as useful predictor of coronary heart disease risk in middle-aged UK men. Arterioscler Thromb Vasc Biol 22(11):1918–1923

    Article  CAS  PubMed  Google Scholar 

  3. Carey VJ, Bishop L, Laranjo N et al (2010) Contribution of high plasma triglycerides and low high-density lipoprotein cholesterol to residual risk of coronary heart disease after establishment of low-density lipoprotein cholesterol control. Am J Cardiol 106(6):757–763

    Article  CAS  PubMed  Google Scholar 

  4. Sarwar N, Danesh J, Eiriksdottir G et al (2007) Triglycerides and the risk of coronary heart disease: 10158 incident cases among 262525 participants in 29 Western prospective studies. Circulation 115(4):450–458

    Article  CAS  PubMed  Google Scholar 

  5. Miller M, Cannon CP, Murphy SA et al (2008) Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial. J Am Coll Cardiol 51(7):724–730

    Article  CAS  PubMed  Google Scholar 

  6. Gaziano JM, Hennekens CH, O’Donnell CJ et al (1997) Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction. Circulation 96(8):2520–2525

    Article  CAS  PubMed  Google Scholar 

  7. Hadaegh F, Khalili D, Ghasemi A et al (2009) Triglyceride/HDL-cholesterol ratio is an independent predictor for coronary heart disease in a population of Iranian men. Nutr Metab Cardiovasc Dis 19(6):401–408

    Article  CAS  PubMed  Google Scholar 

  8. Paramsothy P, Katz R, Owens DS et al (2010) Age-modification of lipoprotein, lipid, and lipoprotein ratio-associated risk for coronary artery calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA]). Am J Cardiol 105(3):352–358

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Bittner V, Johnson BD, Zineh I et al (2009) The TG/HDL cholesterol ratio predicts all cause mortality in women with suspected myocardial ischemia a report from the Women’s Ischemia Syndrome Evaluation (WISE). Am Heart J 157(3):548–555

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Kannel WB, Vasan RS, Keyes MJ et al (2008) Usefulness of the triglyceride–high-density lipoprotein versus the cholesterol–high-density lipoprotein ratio for predicting insulin resistance and cardiometabolic risk (from the framingham offspring cohort). Am J Cardiol 101(4):497–501

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Bertoluci MC, Quadros AS, Sarmento-Leite R et al (2010) Insulin resistance and triglyceride/HDLc index are associated with coronary artery disease. Diabetol Metab Syndr 2:11

    Article  PubMed Central  PubMed  Google Scholar 

  12. Gensini GG (1983) A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 51(3):606

    Article  CAS  PubMed  Google Scholar 

  13. Frohlich J, Dobiasova M (2003) Fractional esterification rate of cholesterol and ratio of triglycerides to HDL-cholesterol are powerful predictors of positive findings on coronary angiography. Clin Chem 49(11):1873–1880

    Article  CAS  PubMed  Google Scholar 

  14. Krauss RM, Blanche PJ (1992) Detection and quantitation of LDL subfractions. Curr Opin Lipidol 3:377–383

    Article  CAS  Google Scholar 

  15. Anber V, Griffin BA, McConnell M et al (1996) Influence of plasma lipid and LDL-subfraction profile on the interaction between low density lipoprotein with human arterial wall proteoglycans. Atherosclerosis 24:261–271

    Article  Google Scholar 

  16. Zambon A, Austin MA, Brown BG et al (1993) Effect of hepatic lipase on LDL in normal men and those with coronary artery disease. Arterioscler Thromb 13:147–153

    Article  CAS  PubMed  Google Scholar 

  17. Hanak V, Munoz J, Teague J et al (2004) Accuracy of the triglyceride to high-density lipoprotein cholesterol ratio for prediction of the low-density lipoprotein phenotype B. Am J Cardiol 94:219–222

    Article  CAS  PubMed  Google Scholar 

  18. Ballantyne CM, Olsson AG, Cook TJ et al (2001) Influence of low high-density lipoprotein cholesterol and elevated triglyceride on coronary heart disease events and response to simvastatin therapy in 4S. Circulation 104:3046–3051

    Article  CAS  PubMed  Google Scholar 

  19. Voight BF, Peloso GM, Otho-Melander M et al (2012) Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet 380(9841):572–580

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Greene DJ, Skeggs JW, Morton RE (2001) Elevated triglyceride content diminishes the capacity of high density lipoprotein to deliver cholesteryl esters via the scavenger receptor class B type I (SR-BI). Biol Chem 276:4804–4811

    Article  CAS  Google Scholar 

  21. Sone H, Tanaka S, Tanaka S et al (2012) Comparison of various lipid variables as predictors of coronary heart disease in Japanese men and women with type 2 diabetes: subanalysis of the Japan diabetes complications study. Diabetes Care

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (30900491) and Young Medical Talents Training Program of Shanghai Municipal Health Bureau (XYQ2011011) to Z.Y. Chen, and Shanghai Technology Innovation Program Basic Research Project (10JC1410502) to G.P. Lu.

Conflict of interest

On behalf of all authors, the corresponding author states that there are no conflicts of interest.

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Authors and Affiliations

  1. Department of Cardiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, Ruijin 2nd Road, Shanghai, China

    Z. Yunke, L. Guoping & C. Zhenyue

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  1. Z. Yunke
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  2. L. Guoping
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  3. C. Zhenyue
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Correspondence to C. Zhenyue.

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Yunke, Z., Guoping, L. & Zhenyue, C. Triglyceride-to-HDL cholesterol ratio. Herz 39, 105–110 (2014). https://doi.org/10.1007/s00059-013-3788-0

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  • DOI: https://doi.org/10.1007/s00059-013-3788-0

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