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Physiological Roles of Mammalian Sulfate Transporters NaS1 and Sat1

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Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

This review summarizes the physiological roles of the renal sulfate transporters NaS1 (Slc13a1) and Sat1 (Slc26a1). NaS1 and Sat1 encode renal anion transporters that mediate proximal tubular sulfate reabsorption and thereby regulate blood sulfate levels. Targeted disruption of murine NaS1 and Sat1 leads to hyposulfatemia and hypersulfaturia. Sat1 null mice also exhibit hyperoxalemia, hyperoxaluria and calcium oxalate urolithiasis. Dysregulation of NaS1 and Sat1 leads to hypersulfaturia, hyposulfatemia and liver damage. Loss of Sat1 leads additionally to hyperoxaluria with hyperoxalemia, nephrocalcinosis and calcium oxalate urolithiasis. These data indicate that the renal anion transporters NaS1 and Sat1 are essential for sulfate and oxalate homeostasis, respectively.

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Abbreviations

NaS1:

Sodium sulfate cotransporter-1

Sat1:

Sulfate anion transporter-1

BBM:

Brush-border membrane

BLM:

Basolateral membrane

DIDS:

4,4′-Diisothiocyanato-2,2′-disulfonate

SITS:

4-Acetamido-4′-isothiocyanato-2,2′-disulfonate

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Acknowledgments

This work was supported in part by the Australian Research Council, the National Health and Medical Research Council of Australia and the Cancer Council Queensland.

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  1. School of Biomedical Sciences, University of Queensland, St. Lucia, QLD, 4072, Australia

    Daniel Markovich

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Correspondence to Daniel Markovich.

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Markovich, D. Physiological Roles of Mammalian Sulfate Transporters NaS1 and Sat1. Arch. Immunol. Ther. Exp. 59, 113–116 (2011). https://doi.org/10.1007/s00005-011-0114-5

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  • DOI: https://doi.org/10.1007/s00005-011-0114-5

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