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Role of Kinins in Inflammatory Responses

Prospects for Drug Therapy

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  • Research Perspective
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Summary

Kinins are ubiquitous mediators that produce many of the cardinal manifestations of inflammation, and for that reason are an important target for therapeutic intervention. The cellular effects produced by the vasoactive kinin peptides are mediated by at least 2 different classes of receptors, B1 and B2. The development of specific, competitive antagonists of these receptors has provided a powerful tool for elucidating the physiopathological actions of kinins.

Considerable evidence from in vitro and animal studies suggests that currently available kinin antagonists are capable of blocking many of the pro-inflammatory effects of kinins. Studies to date in humans are encouraging, but not conclusive. The next few years should provide much information on the clinical potential of this exciting new class of components.

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Authors and Affiliations

  1. Cortech Inc., Denver, Colorado, USA

    Timothy C. Rodell

  2. Department of Experimental and Clinical Pharmacology, Medical School, University of Natal, P.O. Box 17039, Congella, 4013, Durban, South Africa

    Yugen Naidoo &  Kanti D. Bhoola

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  1. Timothy C. Rodell
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  2. Yugen Naidoo
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  3. Kanti D. Bhoola
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Rodell, T.C., Naidoo, Y. & Bhoola, K.D. Role of Kinins in Inflammatory Responses. Clin. Immunother. 3, 352–361 (1995). https://doi.org/10.1007/BF03259501

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