Abstract
A 62-year-old woman with metastatic papillary thyroid carcinoma in the sternum was successfully treated with percutaneous ethanol injection therapy (PEIT) when previous radioiodine therapy and external irradiation were ineffective. The patient tolerated the treatment well and the refractory pain in the anterior chest wall that was alleviated with morphine prior to PEIT completely disappeared. No severe complications were observed. PEIT was performed 4 times (2 times with ultrasound guidance and 2 times with CT guidance). The posttreatment CT scan and201T1 scintigraphy demonstrated significant decrease in the tumor volume. The serum thyroglobulin level fell to less than one-twentieth of the pretreatment value. It is suggested that PEIT has a value in treating bone metastasis from thyroid carcinoma which do not respond to radioiodine.
Similar content being viewed by others
References
Harness JK, Thompson NW, Sisson JC, Beierwalts WM. Differentiated thyroid carcinomas. Treatment of distant metastases.Arch Surg 108: 410–417, 1974.
Brown AP, Greening WP, McCready VR, Shaw HJ, Harmer CL. Radioiodine treatment of metastatic thyroid carcinoma: The Royal Marseden Hospital experience.Br J Radiol 57: 323–327, 1984.
Massin JP, Savoie JC, Gamier H, Guiraudon G, Leger FA, Bacourt F. Pulmonary metastases in differentiated thyroid carcinoma.Cancer 53: 982–992, 1984.
Harbert JC.Nuclear Medicine Therapy. New York, USA, Thieme Medical Publishers, Inc., p. 70, 1987.
Yamauchi T, Noguchi S, Murakami N, Yamaguchi K, Imura M, Taniguchi M. An ethanol injection therapy for tumors of inoperable patients with a differentiated thyroid carcinoma.Jpn J Cancer Clin 37: 1035–1038, 1991.
Kanoh T, Endoh K, Hamada Y, Andoh T, Kobayashi J, Makita F, et al. Report of a case of recurrent thyroid carcinoma treated with percutaneous ethanol injections.Jpn J Cancer Clin 41: 893–897, 1995.
Nakada K, Furudate M. Percutaneous ethanol injection therapy for unresectable recurrent thyroid carcinoma.Endocrine Surgery 12: 141–146, 1995.
Chung TC, Sagerman RH, Ryoo MC, King GA, Yu WS, Dalai PS, et al. External irradiation for malignant thyroid tumors.Radiology 136: 753–756, 1980.
Nakada K, Katoh C, Kanegae K, Tsukamoto E, Itoh K, Tamaki N. Percutaneous ethanol injection therapy for autonomously functioning thyroid nodules.Ann Nucl Med 10: 171–176, 1996.
Monzani F, Goletti O, Caraccio N, Del Guerra P, Ferdeghini M, Pucci E, et al. Percutaneous ethanol injection treatment of autonomously thyroid adenoma: hormonal and clinical evaluation.Clin Endocrinol 36: 491–497, 1992.
Martino E, Murtas ML, Loviselli A, Piga M, Petrini L, Miccoli P, et al. Percutaneous intranodular ethanol injection for treatment of autonomously functioning thyroid nodules.Surgery 112: 1161–1165, 1992.
Mazzeo S, Toni MG, De Gaudio C, Caramella D, Pinto F, Lencioni P, et al. Percutaneous injection of ethanol to treat autonomous thyroid nodules.AJR 161: 871–876, 1993.
Shinagawa T, Ukaji H, Iino Y, Isomura S, Yamaguchi H, Ishizuka S, et al. Intratumoral injection of absolute ethanol under ultrasound imaging for treatment of small hepatocellular carcinoma.Acta Hepatol Jpn 26: 99–105, 1985.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nakada, K., Kasai, K., Watanabe, Y. et al. Treatment of radioiodine-negative bone metastasis from papillary thyroid carcinoma with percutaneous ethanol injection therapy. Ann Nucl Med 10, 441–444 (1996). https://doi.org/10.1007/BF03164808
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF03164808