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Effects of chronic antidepressant treatment of β-adrenoceptor subtype binding in the rat cerebral cortex and cerebellum

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Molecular and Chemical Neuropathology

Abstract

The effects of desipramine, tranylcypromine, and phenelzine on β-adrenoceptor subtype binding were measured in rat cerebral cortex and cerebellum. The drugs were administered to male Sprague Dawley rats for 28 d sc via 2ML4 Alzet osmotic minipumps (desipramine HCl 10, tranylcypromine HCl 1, phenelzine sulfate 5, 10 mg kg−1/d). Binding of [3H]CGP 12177 was measured to determine total β-adrenoceptor density in each brain region. The relative densities of β1 and β2-adrenoceptors were directly calculated from competition analysis using ICI 89406 to displace [3H]CGP 12177. β1-Adrenoceptor density was decreased in cortical tissue following each antidepressant treatment, but no effects on β2-adrenoceptor density were evident. With cerebellar tissue, despite a higher density of β2-adrenoceptors in this area, no effects of antidepressants on β2-adrenoceptor density were evident. The present data confirm and extend previous reports of β1- but not β2-adrenoceoptor downregulation in brain following chronic antidepressant drug treatment.

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Authors and Affiliations

  1. Neurochemical Research Unit, Department of Psychiatry, University of Alberta, T6G 2B7, Edmonton, Alberta, Canada

    Paul Raymond Paetsch & Andrew James Greenshaw

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  1. Paul Raymond Paetsch
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  2. Andrew James Greenshaw
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Paetsch, P.R., Greenshaw, A.J. Effects of chronic antidepressant treatment of β-adrenoceptor subtype binding in the rat cerebral cortex and cerebellum. Molecular and Chemical Neuropathology 20, 21–31 (1993). https://doi.org/10.1007/BF03160067

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  • DOI: https://doi.org/10.1007/BF03160067

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