Abstract
Vancomycin is becoming increasingly used for prophylaxis, and treatment against resistantforms of penicillinase-producing staphylococci. This drug, and the aminoglycosides as a group, have serious side-effects and organ toxicity, and may interact with anaesthetic drugs, particularly muscle relaxants. Two cases of anaphylactoid reactions to vancomycin are reported. The first patient subsequently developed oliguria and marked oedema, while the second developed non-cardiogenic pulmonary oedema.
Résumé
La vancomycin est de plus en plus employée comme agent prophylactique et thérapeutique contre les formes résistantes de staphylocoques produisant la pénicillinase. Cette drogue, ainsi que les aminosides comme groupe, présente des effets secondaires sérieux ainsi qu’une toxicité organique et peut interagir avec les médicaments anesthésiques, plus particulièrement les relaxants musculaires. Deux cas de réaction anaphylactoîde à la vancomycin sont rapportés. Le premier patient a développé subséquemmenl une oligurie et un oedème marqué alors que le second a développé un oedème pulmonaire non-cardiogénique.
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Symons, N.L.P., Hobbes, A.F.T. & Leaver, H.K. Anaphylactoid reactions to vancomycin during anaesthesia: two clinical reports. Can Anaesth Soc J 32, 178–181 (1985). https://doi.org/10.1007/BF03010047
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DOI: https://doi.org/10.1007/BF03010047