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Histological and histochemical skin changes in insulin-dependent diabetic patients with and without limited joint mobility

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Summary

We studied 24 skin biopsies of the hand in 24 IDDM patients followed at the National Institute of Endocrinology (NIE). Biopsies of 7 healthy individuals were used as controls. The diabetics were divided into two groups, with limited joint mobility (LJM) and without LJM. We compared the different structural components of the skin, and their changes; we used quantitative, semi-quantitative and qualitative methods. We found that patients with LJM had a greater levelling, less rete pegs and dermal papillae (p<0.05), increased alteration of the mucopolysaccharides distribution (p<0.005), higher frequency of alterations of the elastic fibers (p<0.05) and collagen (p<0.005), vessel enlargement (p<0.025) acquiring cord shape, and reduction of the vessel lumen (p<0.005) in comparison with patients without LJM and controls. This could be a consequence of the chronic hyperglycemia from childhood that affects the structure, architecture and function of collagen fibers. Genetic and immunologic studies could help to elucidate the mechanisms of this alteration.

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Authors and Affiliations

  1. Instituto Nacional de Endocrinología, Zapata y D, Vedado, Ciudad de la Habana, Cuba

    Manuel Vera & Ricardo Guell

  2. University of Sofia, Bulgaria

    Georgy Shumkov

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  1. Manuel Vera
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  2. Georgy Shumkov
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  3. Ricardo Guell
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Vera, M., Shumkov, G. & Guell, R. Histological and histochemical skin changes in insulin-dependent diabetic patients with and without limited joint mobility. Acta diabet. lat 24, 101–108 (1987). https://doi.org/10.1007/BF02742848

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  • DOI: https://doi.org/10.1007/BF02742848

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