Summary
Systemic Sclerosis (SSc; scleroderma) is associated with several immunological abnormalities, including altered proportion between lymphocyte subsets. Peripheral blood lymphocyte subsets from 25 patients with SSc were studied by two-colour flow cytometry using monoclonal antibodies against CD45RA and CD29 markers, which allow a dissection of CD4+ and CD8+ populations into ‘naive’ and ‘memory’ subsets. A decrease of the percentage of CD8+ (p<0.05) and of CD8+ CD29+ (p<0.001) cells was observed compared to that in 20 age and sex-matched controls. These abnormalities were not significantly associated with the extension of cutaneous disease or other clinical features of SSc nor with treatment, pattern of autoantibodies or HLA phenotype.
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Gorla, R., Airo', P., Malagoli, A. et al. CD4+ and CD8+ subsets: Naive and memory cells in the peripheral blood of patients with systemic sclerosis. Clin Rheumatol 13, 83–87 (1994). https://doi.org/10.1007/BF02229871
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DOI: https://doi.org/10.1007/BF02229871