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Functional characteristics of canine pylorus in health, with pyloroplasty, and after pyloric reconstruction

  • Motility, Nerve-Gut Interactions, Hormones, and Receptors
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Abstract

The aim was to determine whether pyloroplasty decreases the strength of pyloric contractions and speeds gastric emptying of solids, while subsequent pyloric reconstruction restores these abnormalities to the control. In conscious dogs, pyloroplasty decreased the strength of pyloroduodenal pressure waves measured with a perfused sleeve sensor [mean ± SEM pyloroduodenal motility index: control (N=7)=1116±351 mm Hg×sec/10 min; pyloroplasty (N=7)=43±19 mm Hg×sec/10 min;P<0.05], and caused rapid gastric emptying of solids measured scintigraphically (mean±SEM half-emptying time: control=246±14 min, pyloroplasty=176±16 min;P<0.05). The frequencies of pyloroduodenal waves and gastric emptying of liquids, however, were unchanged. Pyloric reconstruction restored the postpyloroplasty patterns to the control. In conclusion, pyloroplasty decreased the strength of pyloroduodenal contractions and sped gastric emptying of solids, while pyloric reconstruction restored the altered patterns to the control.

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References

  1. Meyer JH, Thomson JB, Cohen MB, Shadchehr A, Mandiola SA: Sieving of solid food by the canine stomach and sieving after gastric surgery. Gastroenterology 76:804–813, 1979

    Google Scholar 

  2. Humphrey CS, Johnston D, Walker BE, Pulvertaft CN, Goligher JC: Incidence of dumping after truncal and selective vagotomy with pyloroplasty and highly selective vagotomy without drainage procedure. Br Med J 3:785–788, 1972

    Google Scholar 

  3. Cheadle WG, Baker PR, Cuschieri A: Pyloric reconstruction for severe vasomotor dumping after vagotomy and pyloroplasty. Ann Surg 202:568–572, 1985

    Google Scholar 

  4. Ebied FH, Ralphs DNL, Hobsley M, LeQuesne LP: Dumping symptoms after vagotomy treated by reversal of pyloroplasty. Br J Surg 69:527–528, 1982

    Google Scholar 

  5. Christiansen PM, Hansen OH, Pedersen T: Reconstruction of the pylorus for postvagotomy diarrhoea and dumping. Br J Surg 61:519–520, 1974

    Google Scholar 

  6. Frederiksen H-JB, Stacher Johansen T, Christiansen PM: Postvagotomy diarrhoea and dumping treated with reconstruction of the pylorus. Scand J Gastroenterol 15:245–248, 1980

    Google Scholar 

  7. Elashoff JD, Reedy TJ, Meyer JH: Analysis of gastric emptying data. Gastroenterology 83:1306–1312, 1982

    Google Scholar 

  8. Heddle R, Miedema BW, Kelly KA: Integration of canine proximal gastric, antral, pyloric and proximal duodenal motility during fasting and after a liquid meal. Dig Dis Sci 38:856–869, 1993

    Google Scholar 

  9. Heddle R, Dent J, Read NW, Houghton LA, Toouli J, Horowitz M, Maddern GJ, Downton J: Antropyloroduodenal motor responses to intraduodenal lipid infusion in healthy volunteers. Am J Physiol 254:G671-G679, 1988

    Google Scholar 

  10. Heddle R, Fone D, Dent J, Horowitz M: Stimulation of pyloric motility by intraduodenal dextrose in normal subjects. Gut 29:1349–1357, 1988

    Google Scholar 

  11. Brink BM, Schlegel JF, Code CF: The pressure profile of the gastroduodenal junctional zone in dogs. Gut 6:163–171, 1965

    Google Scholar 

  12. Valenzuela JE, Defilippi C, Csendes A: Manometric studies on the human pyloric sphineter. Effect of eigarette smoking, metoclopramide and atropine. Gastroenterology 70:481–483, 1976

    Google Scholar 

  13. Allescher HD, Daniel EE, Dent J, Fox JE, Kostolanska F: Extrinsic and intrinsic neural control of pyloric sphineter pressure in the dog. J Physiol (London) 401:17–38, 1988

    Google Scholar 

  14. Anvari M, Myers J, Horowitz M, Dent J, Jamieson GG: Pattern of antropyloroduodenal motor activity after vagotomy and pyloroplasty in fed state. Gastroenterology 104:A471, 1993

    Google Scholar 

  15. Yamagishi T, Debas HT: Control of gastric emptying: interaction of the vagus and pyloric antrum. Ann Surg 187:91–94, 1978

    Google Scholar 

  16. Mroz CT, Kelly KA: The role of the extrinsic antral nerves in the regulation of gastric emptying. Surg Gynecol Obstet 145:369–377, 1977

    Google Scholar 

  17. Gleysteen JJ, Burdeshaw JA, Hallenbeck GA: Gastric emptying of liquids after different vagotomies and pyloroplasty. Surg Gynecol Obstet 142:41–48, 1976

    Google Scholar 

  18. Wilbur BG, KelleyKA: Effect of proximal gastric, complete gastric and truncal vagotomy on canine gastric electric activity, motility and emptying. Ann Surg 178:295–302, 1973

    Google Scholar 

  19. Hould F-S, Cullen JJ, Kelly KA: Influence of proximal gastric vagotomy on canine gastric motility and emptying. Surgery 116:83–89, 1994

    Google Scholar 

  20. Weddle COI, Springfield AC, Ormsbee HSI, Bass P: Parietal cell vagotomy and gastric emptying of liquids in the dog. Arch Surg 108:83–86, 1974

    Google Scholar 

  21. Kelly KA, Becker JM, van Heerden JH: Reconstructive gastric surgery. Br J Surg 68:687–691, 1981

    Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, 13400 E. Shea Blvd., Scottsdale, Arizona

    Joseph J. Cullen MD &  Keith A. Kelly MD

  2. Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, 55905, Rochester, Minnesota

    Joseph J. Cullen MD &  Keith A. Kelly MD

Authors
  1. Joseph J. Cullen MD
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  2. Keith A. Kelly MD
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Supported by USPHS NIH grants DK18278 and DK07198 and the Mayo Foundation.

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Cullen, J.J., Kelly, K.A. Functional characteristics of canine pylorus in health, with pyloroplasty, and after pyloric reconstruction. Digest Dis Sci 41, 711–719 (1996). https://doi.org/10.1007/BF02213127

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  • DOI: https://doi.org/10.1007/BF02213127

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