Summary
We studied 52 patients with lobular carcinoma in situ (LCIS) of the breast, tissue being available from both breasts in 46 patients. Detailed histological examination of the tissue was combined with specimen radiography. By this technique, six invasive cancers were detected within 2 years of the primary diagnosis. Five of these six carcinomas were clinically occult and were not suspected at specimen radiography. Three other invasive cancers were discovered 4 years, 7 years, and 10 years after diagnosing LCIS. The extent of the LCIS in the primary biopsy was the only feature which gave a guide to the possible presence and location of an occult invasive lesion.
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References
Andersen JA (1977) Lobular carcinoma in situ of the breast. An approach to rational treatment. Cancer 39: 2597–2602
Carter D, Smith RL (1977) Carcinoma in situ of the breast. Cancer 40: 1189–1193
Foote FW, Stewart FW (1941) Lobular carcinoma in situ: A rare form of mammary cancer. Am J Pathol 17: 491–495
Fournier DV, Weber E, Hoeffken W, Bauer M, Kubli F, Bath V (1980) Growth rate of 147 mammary carcinomas. Cancer 45: 2198–2207
Haagensen CD, Lane N, Lattes R, Bodian C (1978) Lobular neoplasia (so-called lobular carcinoma in situ) of the breast. Cancer 42: 737–769
Flutter RVP, Foote FW (1969) Lobular carcinoma in situ. Long term follow-up. Cancer 24: 1081–1085
McDivitt RW, Hutter RVP, Foote FW, Stewart FW (1967) In situ lobular carcinoma. A prospective follow-up study indicating cumulative patients risk. JAMA 201: 82–86
Müller A, Tschahargane C, Bothmann GA, Kublin F (1980) Morphologische Befunde bei subkutanen Mastektomien. Untersuchung an 200 Patientinnen. Referat, gehalten am I. Internat. Kongreß für Senologie, Mai 1980, Hamburg
Rosen PP, Liebermann PH (1978) Lobular carcinoma in situ: Preliminary results of a long term follow-up study. In: Grundmann E, Beck L (eds) Early diagnosis of breast cancer (Cancer campaign series, vol I). Fischer, New York, pp 119–127
Rosen PP, Senie R, Schottenfeld D, Ashikari R (1979) Noninvasive breast carcinoma. Frequency of unsuspected invasion and implications for treatment. Ann Surg 189: 377–382
Rosen PP, Braun DW, Kinne DE (1980) The clinical significance of pre-invasive breast carcinoma. Cancer 46: 919–925
Rosen PP, Braun DW, Lyngholm B, Urban JE, Kinne DW (1981) Lobular carcinoma in situ of the breast: Preliminary results of treatment by ipsilateral mastectomy and contralateral breast biopsy. Cancer 47: 813–819
Rummel W, Kindermann G, Egger H, Weishaar J, Müller A, Paterok EM, Willgeroth F (1976) Mikrokalk in der Mammographie, operative Abklärung und histologische Befunde. Geburtshilfe Frauenheilkd 36: 1053–1061
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Tulusan, A.H., Egger, H., Schneider, M.L. et al. A contribution to the natural history of breast cancer. Arch. Gynecol. 231, 219–226 (1982). https://doi.org/10.1007/BF02110121
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DOI: https://doi.org/10.1007/BF02110121