Abstract
We studied the effects of a sphincter substitute on motility in the intestinal remnant following an extensive distal intestinal resection. Two groups of adult dogs were studied; each underwent a 75% resection of the distal small intestine, and in one group a nipple valve was fashioned at the distal end of the remnant. Nutritional status, absorptive function, motility, and transit were studied over a three-month period. While the nipple valve animals had less diarrhea, steatorrhea, and hypoalbuminemia, motor activity and transit were similar in both groups. Thus, in both groups, fasting motor activity was dominated by clusters of phasic pressure activity. (Cluster frequency, per hour, mean±se, resection vs resection with nipple valve: 4.8±1.05 vs 3.58±0.54, NS). We conclude that the beneficial effects of a sphincter substitute in ameliorating the short bowel syndrome in this dog model are not related to any modification of the motor response to resection but may simply reflect those of a low-grade mechanical obstruction.
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References
Thompson JS: Surgical therapy for the short bowel syndrome. J Surg Res 39:81–91, 1985
Williamson RCN: Intestinal adaptation. Structural, functional and cytokinetic changes. N Engl J Med 298:1393–1402, 1978
Williamson RCN: Intestinal adaptation. Mechanisms of control. N Engl J Med 298:1444–1450, 1978
Quigley EMM, Thompson JS: The intestinal motor response to resection. Gastroenterology 105:791–798, 1993
Quigley EMM: The effects of resection, restorative procedures and transplantation on intestinal motility.In An Illustrated Guide to Gastrointestinal Motility, 2nd ed. D Kumar, DL Wingate (eds). Edinburgh, Churchill Livingstone, pp 691–716, 1994
Quigley EMM, Thompson JS, Lof J: Disruption of jejunal interdigestive myoelectrical activity by an artificial ileocecal sphincter. Studies of the intestinal motor response to a surgically-fashioned sphincter substitute. Dig Dis Sci 34:1434–1442, 1989
Van De Kamer JH, Huinink TB, Weyers HA: Rapid method for the determination of fat in feces. J Biol Chem 177:347–355, 1949
Code CF, Marlett JA: The interdigestive myoelectric complex of the stomach and small bowel of dogs. J Physiol 296:289–309, 1975
Quigley EMM, Phillips SF, Dent J: Distinctive patterns of interdigestive motility at the canine ileocolonic junction. Gastroenterology 87:836–844, 1984
Quigley EMM, Borody TJ, Phillips SF, Wienbeck M, Tucker RL, Haddad AC: Motility of the terminal ileum and ileocecal sphincter in healthy man. Gastroenterology 87:857–866, 1984
Pigot F, Messing B, Chaussade S, Pfeiffer A, Pouliquen X, Jian R: Severe short bowel syndrome with a surgically reversed small bowel segment. Dig Dis Sci 35:137–144, 1990
Kamath PS, Phillips SF: Initiation of motility in canine ileum by short chain fatty acids and inhibition by pharmacological agents. Gut 29:941–948, 1988
Kamath PS, Hoepfner MT, Phillips S: Short chain fatty acids stimulate motility of the canine ileum. Am J Physiol 16:G427-G433, 1987
Kamath PS, Phillips SF, Zinmeister AR: Short chain fatty acids stimulate ileal motility in humans. Gastroenterology 95:1496–1502, 1988
Fich A, Phillips SF, Hakim NS, Brown ML, Zinmeister AR: Stimulation of ileal emptying by short chain fatty acids. Dig Dis Sci 34:1516–1520, 1989
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Supported by the Veterans Administration Merit Review Program.
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Quigley, E.M.M., Thompson, J.S. Effects of artificial ileocolonic sphincter on motility in intestinal remnant following subtotal small intestinal resection in the dog. Digest Dis Sci 39, 1222–1228 (1994). https://doi.org/10.1007/BF02093787
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DOI: https://doi.org/10.1007/BF02093787