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Cystic encephalomalacia and intrauterine herpes simplex virus infection

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Abstract

Cystic encephalomalacia occurred in two preterm infants who had proven intrauterine herpes simplex virus type 2 infection. Calcification was evident in the basal ganglia. Follow-up scans indicated that the cysts had resolved over a period of two months in one infant, while in the case of the other, the cysts became progressively larger with significant ventricular dilatation developing. While cystic changes in the brain of preterm infants are usually due to periventricular leukomalacia intrauterine infection needs to be considered as a possible cause. Antiviral treatment may be of benefit to infants with herpes simplex virus infection.

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References

  1. Slovis TL, Shankaran S, Bedard MP, Poland RL (1984) Intracranial haemorrhage in the hypoxic-ischaemic infant: ultrasound demonstration of unusual complications. Radiology 154: 163

    Google Scholar 

  2. Hughes HE, Miskin M (1986) Congenital microcephaly due to vascular disruption in utero documentation. Pediatr 78: 85

    Google Scholar 

  3. Stannard MW, Jimenez (1983) Sonographic recognition of multiple cystic encephalomalacia. AJR 141: 1321

    PubMed  Google Scholar 

  4. Bale JF Jr, Bray PF, Bell WE (1985) Neuroradiographic abnormalities in congenital cytomegalovirus infection. Ped Neurol 1: 42

    Google Scholar 

  5. Whitley RJ (1988) Neonatal herpes simplex virus infections. Clin Perinatol 15: 903

    PubMed  Google Scholar 

  6. Herman TE, Cleveland RH, Kushner DC, Taveras JM (1985) CT of neonatal herpes encephalitis. AJNR 6: 773

    PubMed  Google Scholar 

  7. Cleveland RH, Herman TE, Oot RF, Kushner DC (1987) The evolution of neonatalherpes encephalitis as demonstrated by cranial ultrasound with CT correlation. Am J Perinatol 4: 215

    PubMed  Google Scholar 

  8. Bale JF, Andersen RD, Grose C (1987) Magnetic resonance imaging of the brain in childhood herpesvirus infections. Pediatr Infect Dis J 6: 644

    PubMed  Google Scholar 

  9. Baldwin S, Whitley RJ (1989) Teratogen update: intrauterine herpes simplex virus infection. Teratology 39: 1

    PubMed  Google Scholar 

  10. Arvin AM, Prober CG (1990) Herpes simplex virus infections. Pediatr Infect Dis J 9: 765

    PubMed  Google Scholar 

  11. Brown ZA, Vontner LA, Benedetti J, Cruichlow CW, Sells CJ, Berry S, Corey L (1987) Effects on infants of a first episode of genital herpes during preganancy. N Engl J Med 317: 1246

    PubMed  Google Scholar 

  12. Sieber OF, Fulginiti VA, Brazie J, Umlauf HJ (1964) In utero infection of the fetus by herpes simplex virus. J Pediatr 69: 30

    Google Scholar 

  13. Suh YL, Kim H, Byun HR, Lee K (1987) Disseminated neonatal herpes simplex virus infection with necrotizing encephalitis. J Korean Med Sci 2: 123

    PubMed  Google Scholar 

  14. Beck R, Park T, Farrington P, Steigman CK, Sennesh JD, Congenital disseminated herpes simplex virus type II infection in a premature infant. Am J Perinatol 4∶334

  15. Toltzis P (1991) Current issues in neonatal herpes simplex virus infection. Clin Perinatol 18: 193

    Google Scholar 

  16. Honig PJ, Brown D (1982) Congenital herpes simplex virus infection initially resembling epidermolysis bullosa. J Pediatr 101: 958

    PubMed  Google Scholar 

  17. South MA, Tompkins WAF, Morris CR, Rawls WE (1969) Congenital malformation of the central nervous system associated with genital type (type 2) herpes virus. J Pediatr 75: 13

    PubMed  Google Scholar 

  18. Hutto C, Arvin A, Jacobs R, Steele R, Stagno S, Lyrene R, Willett L, Powell D, Andersen R, Werthammer J, Ratcliff G, Nahmias A, Christy C, Whitley R (1987) Intrauterine herpes simplex virus infections. J Pediatr 110: 97

    PubMed  Google Scholar 

  19. Rabalais GP, Adams G, Yusk JW, Wilkerson SA (1991) Zosteriform denuded skin caused by intrauterine herpes simplex virus infection. Pediatr Infect Dis J 10: 79

    PubMed  Google Scholar 

  20. Parish WR (1989) Intrauterine herpes simplex virus infection. Int J Dermatol 28: 397

    PubMed  Google Scholar 

  21. Pidcock FS, Graziani LJ, Stanley C, Mitchell DG, Merton D (1990) Neurosonographic features of periventricular echodensities associated with cerebral palsy in preterm infants. J Pediatr 116: 417

    PubMed  Google Scholar 

  22. Teele RL, Hernanz-Schulman M, Sotrel A (1988) Echogenic vasculature in the basal ganglia of neonates: a sonographic sign of vasculopathy. Radiology 169: 423

    PubMed  Google Scholar 

  23. Sinha SK, D'Souza SW, Rivlin E, Chiswick ML (1990) Ischaemic brain lesions diagnosed at birth in preterm infants: clinical events and developmental outcome. Arch Dis Child 65: 1017

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Mater Mothers' Hospital, Raymond Terrace, 4101, South Brisbane, QLD, Australia

    P. H. Gray (Staff Neonatologist), D. I. Tudehope & J. Masel

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  1. P. H. Gray
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  2. D. I. Tudehope
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  3. J. Masel
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Gray, P.H., Tudehope, D.I. & Masel, J. Cystic encephalomalacia and intrauterine herpes simplex virus infection. Pediatr Radiol 22, 529–532 (1992). https://doi.org/10.1007/BF02013003

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  • DOI: https://doi.org/10.1007/BF02013003

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