Abstract
The microradiographic-photometric method of studying the X-ray absorption, and the microhardness testing technique were concurrently applied to investigate the rate of secondary mineralization of bone of known age in the osteons of young immature and adult dogs.
The results of the two series of measurement show a close agreement. They indicate that the rate of secondary mineralization, (a) slowly and progressively decreases with time in each osteon, (b) undergoes little variations in the various osteons of each subject independently of the reconstruction rate characteristic of each skeletal region, and (c) markedly decreases with the ageing of the animal.
Résumé
La méthode microradiographique-photométrique d'étude de l'absorption de rayons X, ainsi que la technique de microdureté, sont utilisées conjointement pour étudier la vitesse de minéralisation secondaire de l'os d'âge connu dans les ostéones de chiens jeunes et adultes. Les résultats des deux séries de mesures montrent une très bonne concordance. Ils montrent que la vitesse de la minéralisation secondaire a) décroit lentement et progressivement avec le temps dans chaque ostéone, b) subit peu de variations dans les divers ostéones de chaque sujet indépendemment de la vitesse de reconstruction, caractéristique de chaque région squelettique et c) décroit nettement avec l'âge de l'animal.
Zusammenfassung
Die photometrische Methode zur Untersuchung der Mikroradiographien und die Mikrotechnik zur Beurteilung der Knochenhärte wurden beide zur Bestimmung der Geschwindigkeit der sekundären Mineralisation von Knochen bekannten Alters in den Osteonen von jungen und ausgewachsenen Hunden angewandt.
Die Resultate beider Meß-Serien stimmten gut überein. Sie zeigten, daß die Geschwindigkeit der sekundären Knochenmineralisation a) mit der Zeit in jedem Osteon langsam und stetig abnimmt; b) kleinen Variationen in den verschiedenen Osteonen von jedem Tier unterliegt, unabhängig von der Neubildungsgeschwindigkeit, die für jede Skelettregion charakteristisch ist; c) mit dem Altern des Tieres beträchtlich abnimmt.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Amprino, R.: Rapporti fra processi di ricostruzione e distribuzione dei minerali nelle ossa. I. Ricerche eseguite col metodo di studio dell'assorbimento dei raggi Roentgen. Z. Zellforsch.37, 144–183 (1952).
Amprino, R.: Investigations on some physical properties of bone tissue. Acta anat. (Basel)34, 161–186 (1958).
Amprino, R., Engström, A.: Studies on X ray absorption and diffraction of bone tissue. Acta anat. (Basel)15, 1–22 (1952).
Amprino, R., Marotti, G.: A topographic quantitative study of bone formation and reconstruction. In: Bone and tooth (H. J. J. Blackwood, ed.), p. 21–33. Oxford-London-New York-Paris: Pergamon Press 1964.
Blaimont, P.: Contribution à l'étude biomécanique du fémur humain. Thèse. Acta orthop. belg.34, 665–844 (1968).
Carlström, D.: Microhardness measurements on single Haversian systems in bone. Experientia (Basel)10, 171–172 (1954).
Engström, A.: Microradiography of normal bone. In: Handbuch der medizinischen Radiologie (L. Diethelm, Hrsg.), S. 296–316. Berlin-Heidelberg-New York: Springer 1970.
Frost, H. M.: A new bone affection: feathering. J. Bone Jt. Surg. A42, 447–456 (1960).
Godina, G.: Trasformazioni strutturali durante l'accrescimento delle ossa lunghe in cani di differente mole somatica. Arch. ital. Anat. Embriol.52, 161–178 (1947).
Harris, W. H., Travis, D. F., Friberg, U., Radin, E.: Thein vivo inhibition of bone formation by Alizarin red S. J. Bone Jt. Surg.A 46, 493–508 (1964).
Jowsey, J.: Variations in bone mineralization with age and disease. In: Bone biodynamics (H. M. Frost, ed.), p. 461–479. Boston: Little, Brown and Company 1964.
Marotti, F., Marotti, G.: Validità dell'impiego delle tetracicline nella valutazione quantitativa della formazione e del rinnovamento del tessuto osseo. Arch. Putti20, 394–409 (1965).
Marotti, G.: Quantitative studies on bone reconstruction. 1. The reconstruction in homotypic shaft bones. Acta anat. (Basel)52, 291–333 (1963).
Marotti, G., Camosso, M. E.: Quantitative analysis of osteonic bone dynamics in the various periods of life. In: Les tissus calcifiés (G. Milhaud, M. Owen and H. J. J. Blackwood, eds.), p. 423–427. Paris: Sedes 1968.
Marshall, J. H.: Measurements and models of skeletal metabolism. In: Mineral metabolism (C. L. Comar and F. Bronner, eds.), vol. III, p. 1–122. New York-London: Academic Press 1969.
Rosate, A.: Variazioni della microdurezza nell'osso primario di bovini di varia età. Arch. Putti18, 391–417 (1963).
Rowland, R. E., Jowsey, J., Marshall, J. H.: Microscopic metabolism of calcium in bone: III. Microradiographic measurements of mineral density. Radiat. Res.10, 234–242 (1959).
Sissons, H. A., Jowsey, J., Stewart, L.: The microradiographic appearance of normal bone tissue at various age. In: X-ray microscopy and microanalysis (A. Engström, V. E. Cosslett and H. H. Pattee, eds.), p. 206–215. Amsterdam-London-New York-Princeton: Elsevier Publ. Co. 1960.
Strandh, J., Norlén, H.: Distribution per volume bone tissue of calcium, phosphorus and nitrogen from individuals of varying ages as compared with distribution per unit weight. Acta orthop. scand.35, 257–263 (1965).
Vincent, J.: Recherches sur la constitution de l'os adulte. Thèse, Bruxelles: Editions Arscia 1955.
Vincent, J.: Les remaniements de l'os compact marqué à l'aide de plomb. Rev. belge Path.26, 161–168 (1957).
Weaver, J. K.: The microscopic hardness of bone. J. Bone Jt. Surg. A48, 273–288 (1966).
Author information
Authors and Affiliations
Additional information
Investigation supported by the Italian National Research Council.
This work is dedicated with great respect to Prof. O. M. Olivo in honour of his 75th birthday.
Rights and permissions
About this article
Cite this article
Marotti, G., Favia, A. & Zallone, A.Z. Quantitative analysis on the rate of secondary bone mineralization. Calc. Tis Res. 10, 67–81 (1972). https://doi.org/10.1007/BF02012537
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02012537