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Diurnal fluctuation in levels of histamine metabolites in cerebrospinal fluid of rhesus monkey

  • Allergy, Histamine and Kinins
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Abstract

In samples of ventricular cerebrospinal fluid (CSF) that were collected from a conscious, restrained rhesus monkey at intervals of 30–90 min, levels of the histamine metabolites,tele-methylhistamine (t-MH) andtele-methylimidazoleacetic acid (t-MIAA), were determined by gas chromatography-mass spectrometry. Levels of t-MH and t-MIAA each showed time-related fluctuations. Peak and trough concentrations of t-MIAA, the product of t-MH, paralleled, but lagged about 2 h behind, the levels of t-MH. Within the first 3 h of illumination, metabolite levels increased more than 3-fold; they fell sharply within the first 3 h of darkness. Mean levels of t-MH and t-MIAA were significantly higher during periods of illumination than of darkness. Fluctuations in the levels ofpros-methylimidazoleacetic acid (p-MIAA), an endogenous isomer of t-MIAA that is not a histamine metabolite, were markedly different from those of t-MH or t-MIAA; p-MIAA levels peaked only at the middle of the dark period. The time-related fluctuations in levels of t-MH and t-MIAA, but not p-MIAA, are similar to the daily rhythmic changes observed in monkey CSF for the levels of other central neurotransmitters and peptide neurohormones.

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  1. R. S. Burns

    Present address: Department of Psychiatry, Vanderbilt University School of Medicine, 37232, Nashville, TN, USA

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  1. Department of Pharmacology, Mount Sinai School of Medicine of the City University of New York, Box 1215, 10029, New York City, New York, USA

    G. D. Prell & J. P. Green

  2. Section on Experimental Therapeutics, NIMH, 20205, Bethesda, MD, USA

    R. S. Burns

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  1. G. D. Prell
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Deceased.

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Prell, G.D., Khandelwal, J.K., Burns, R.S. et al. Diurnal fluctuation in levels of histamine metabolites in cerebrospinal fluid of rhesus monkey. Agents and Actions 26, 279–286 (1989). https://doi.org/10.1007/BF01967291

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